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Lumateperone

Name: Lumateperone
Brand: TargetMol
SKU: T21069
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21069Cas No. 313368-91-1

Alias ITI722, ITI-007, ITI007, ITI 722

Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).

Lumateperone

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Purity: 99.91%

Catalog No. T21069Alias ITI722, ITI-007, ITI007, ITI 722Cas No. 313368-91-1

Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$45	In Stock	In Stock
50 mg	$60	In Stock	In Stock
100 mg	$89	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).
In vivo	ITI-722 was evaluated in the rat quipazine head twitch model induced by quipazine which is a 5-HT2A agonist, ITI-722 have ED50 values of 0.12 mg/kg.
Synonyms	ITI722, ITI-007, ITI007, ITI 722

Chemical Properties

Molecular Weight	393.5
Formula	C₂₄H₂₈FN₃O
Cas No.	313368-91-1
Smiles	[H][C@]12CCN(CCCC(=O)c3ccc(F)cc3)C[C@@]1([H])c1cccc3N(C)CCN2c13
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.94 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5413 mL	12.7065 mL	25.4130 mL	127.0648 mL
5 mM	0.5083 mL	2.5413 mL	5.0826 mL	25.4130 mL
10 mM	0.2541 mL	1.2706 mL	2.5413 mL	12.7065 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc