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Pyraclostrobin

Name: Pyraclostrobin
Brand: TargetMol
SKU: T9491
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9491Cas No. 175013-18-0

Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

Pyraclostrobin

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Purity: 99.89%

Catalog No. T9491Cas No. 175013-18-0

Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$40	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$106	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.89%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR LCMS

Product Introduction

Pyraclostrobin AI Summary

Pyraclostrobin demonstrates significant bioactivity as an inhibitor of the Chagas Disease parasite Trypanosoma cruzi in vitro, with an IC50 value of 6460 nM and cytotoxicity against L-6 rat myoblasts with an IC50 value of 43360 nM. It exhibits multiple bioactivities, acting as an agonist of estrogen receptor alpha (158.5 nM) and androgen receptor signaling (1778.3 nM), an antagonist of thyroid hormone receptor beta (6309.6 nM) and farnesoid X receptor signaling (4466.8 nM), and functions as both an agonist and antagonist of peroxisome proliferator-activated receptor delta signaling with differing potencies (6309.6 nM and 2511.9 nM, respectively). It also serves as an antagonist of retinoid X receptor alpha (3162.3 nM) and activates the nuclear factor-kappa B (NF-kB) and p53 signaling pathways (39810.7 nM and 5011.9 nM respectively), among other signaling pathways. Additionally, Pyraclostrobin has demonstrated broad antifungal activity against various fungal pathogens, including Rhizoctonia solani, Pythium ultimum, Pestalotiopsis microspora, Monilinia laxa, Pyrenophora tritici-repentis, Botryotinia fuckeliana, Fusarium graminearum, and multiple other fungal isolates. It shows low EC50 values, indicating potent inhibition of mycelial growth, conidium germination, and overcoming resistance in mutant strains. Furthermore, it effectively inhibits heart cytochrome bc1 complex in Sus scrofa with a Ki of 3.3 nM. Overall, Pyraclostrobin exhibits immense potential as an antifungal agent and bioactivity modulator in various biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

Chemical Properties

Molecular Weight	387.82
Formula	C₁₉H₁₈ClN₃O₄
Cas No.	175013-18-0
Smiles	N(C(OC)=O)(OC)C1=C(COC2=NN(C=C2)C3=CC=C(Cl)C=C3)C=CC=C1
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (644.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5785 mL	12.8926 mL	25.7852 mL	128.9258 mL
5 mM	0.5157 mL	2.5785 mL	5.1570 mL	25.7852 mL
10 mM	0.2579 mL	1.2893 mL	2.5785 mL	12.8926 mL
20 mM	0.1289 mL	0.6446 mL	1.2893 mL	6.4463 mL
50 mM	0.0516 mL	0.2579 mL	0.5157 mL	2.5785 mL
100 mM	0.0258 mL	0.1289 mL	0.2579 mL	1.2893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc