DcR1/TRAILR3 Protein, Human, Recombinant (His)

Name: DcR1/TRAILR3 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04722
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: tumor necrosis factor receptor superfamily member 10c, TRID, TRAIL-R3, TRAILR3, LIT, DCR1-TNFR, DCR1, CD263) Copy Product Info

Synonyms: tumor necrosis factor receptor superfamily member 10c, TRID, TRAIL-R3, TRAILR3, LIT, DCR1-TNFR, DCR1, CD263

Catalog No. TMPY-04722 Copy Product Info

Purity: 97.5%

TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.

DcR1/TRAILR3 Protein, Human, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 µg	$40	-	In Stock
10 µg	$61	-	In Stock
20 µg	$97	-	In Stock
50 µg	$185	-	In Stock
100 µg	$308	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.5%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1.Measured by its binding ability in a functional ELISA. 2. Immobilized human TNFRSF10C at 10μg/mL (100μL/well) can bind biotinylated human TNFSF10 (10409-HNAE), the EC50 of biotinylated human TNFSF10 is 0.1-0.7μg/mL.
Description	TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	O14798
Construction	A DNA sequence encoding the human TNFRSF10C (NP_003832.2) (Met1-Pro235) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 26
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	tumor necrosis factor receptor superfamily member 10c, TRID, TRAIL-R3, TRAILR3, LIT, DCR1-TNFR, DCR1, CD263
Research Background	TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.

Chemical Properties

Molecular Weight

23.6 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.