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DcR1/TRAILR3 Protein, Human, Recombinant (His)

Catalog No. TMPY-04722
Synonyms: TRAILR3, TRID, DCR1, TRAIL-R3, CD263, DCR1-TNFR, tumor necrosis factor receptor superfamily member 10c, LIT

TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
DcR1/TRAILR3 Protein, Human, Recombinant (His)
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100 μg In stock $ 308.00
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Biological Description
Technical Params
Product Properties
Biological Information 1.Measured by its binding ability in a functional ELISA. 2. Immobilized human TNFRSF10C at 10μg/mL (100μL/well) can bind biotinylated human TNFSF10 (10409-HNAE), the EC50 of biotinylated human TNFSF10 is 0.1-0.7μg/mL.
Description TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.
Species Human
Expression System HEK293
Tag His
Accession Number O14798
Synonyms TRAILR3, TRID, DCR1, TRAIL-R3, CD263, DCR1-TNFR, tumor necrosis factor receptor superfamily member 10c, LIT
Construction A DNA sequence encoding the human TNFRSF10C (NP_003832.2) (Met1-Pro235) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight Approxiamtely 23.6 kDa
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Formulation Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC.

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Keywords

DcR1/TRAILR3 Protein, Human, Recombinant (His) TRAILR3 TRID DCR1 TRAIL-R3 CD263 TRAILR-3 TRAILR 3 DCR 1 DCR1-TNFR tumor necrosis factor receptor superfamily member 10c DCR-1 CD-263 LIT CD 263 recombinant recombinant-proteins proteins protein

 

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