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Anti-VCAM-1 Antibody-APC (5S896)
🥰Excellent
Catalog No. TMAY-00287A
Anti-VCAM-1 Antibody-APC (5S896) is a APC-conjugated Rabbit antibody targeting VCAM-1. Anti-VCAM-1 Antibody-APC (5S896) can be used in FCM.
Anti-VCAM-1 Antibody-APC (5S896)
Anti-VCAM-1 Antibody-APC (5S896)
🥰Excellent
Catalog No. TMAY-00287A
Anti-VCAM-1 Antibody-APC (5S896) is a APC-conjugated Rabbit antibody targeting VCAM-1. Anti-VCAM-1 Antibody-APC (5S896) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
| Description | Anti-VCAM-1 Antibody-APC (5S896) is a APC-conjugated Rabbit antibody targeting VCAM-1. Anti-VCAM-1 Antibody-APC (5S896) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5S896 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human VCAM1 expression on HUT78 cells. Cells were stained with APC-conjugated anti-Human VCAM1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human VCAM-1 / CD106 (rh VCAM-1 / CD106; NP_001069.1Met1-Pro697) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human VCAM-1 / CD106 Protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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