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SHMT-IN-2

Name: SHMT-IN-2
Brand: TargetMol
SKU: T62404
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62404Cas No. 2102681-49-0

SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.

SHMT-IN-2

🥰Excellent

Purity: 99.79%

Catalog No. T62404Cas No. 2102681-49-0

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$178	In Stock
10 mg	$289	In Stock
25 mg	$578	In Stock
50 mg	$928	In Stock
100 mg	$1,250	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	431.45
Formula	C₂₂H₂₄F₃N₅O
Cas No.	2102681-49-0
Smiles	CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (208.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3178 mL	11.5888 mL	23.1777 mL	115.8883 mL
5 mM	0.4636 mL	2.3178 mL	4.6355 mL	23.1777 mL
10 mM	0.2318 mL	1.1589 mL	2.3178 mL	11.5888 mL
20 mM	0.1159 mL	0.5794 mL	1.1589 mL	5.7944 mL
50 mM	0.0464 mL	0.2318 mL	0.4636 mL	2.3178 mL
100 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1589 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc