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AY 77
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Catalog No. T41190Cas No. 1835734-92-3
Alias Unk-Cha-Chg-NH2
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
AY 77
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Purity: 99.7%
Catalog No. T41190Alias Unk-Cha-Chg-NH2Cas No. 1835734-92-3
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $533 | - | In Stock | |
| 10 mg | $713 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock | |
| 50 mg | $1,430 | - | In Stock | |
| 100 mg | $1,930 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.7%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
AY 77 AI Summary
AY 77 exhibits agonist activity at human PAR2 receptors expressed in CHO cells and EA.hy926 cells. It induces intracellular calcium release, with an EC50 value of 31.62 nM to 270.0 nM, measured using a Fluo-3 AM dye-based fluorescence assay. Additionally, it stimulates Galphaq-stimulated IP1 formation with an EC50 of 170.0 nM and 110.0% efficacy compared to a reference compound. AY 77 also induces beta-arrestin recruitment with an EC50 of 2000.0 nM and 94.0% efficacy relative to the reference compound..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro. |
| Synonyms | Unk-Cha-Chg-NH2 |
| Molecular Weight | 404.5 |
| Formula | C21H32N4O4 |
| Cas No. | 1835734-92-3 |
| Smiles | [C@H](CC1CCCCC1)(C(N[C@H](C(N)=O)[C@@H]2CCCCC2)=O)NC(=O)C3=CC=NO3 |
| Relative Density. | 1.183 g/cm3 (Predicted) |
| Sequence | {5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2 |
| Sequence Short | {5-Isoxazolylcarbonyl-Cha}-{Chg} |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Ethanol: 0.9 mg/mL (2.22 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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