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ZLN024

Name: ZLN024
Brand: TargetMol
SKU: T13411
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13411Cas No. 723249-01-2

ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

ZLN024

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Purity: 99.75%

Catalog No. T13411Cas No. 723249-01-2

ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$476	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$912	In Stock	In Stock
200 mg	$1,190	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
Targets&IC50	AMPK α2β2γ1:0.13 μM (EC50), AMPK α1β1γ1:0.42 μM (EC50), AMPK α1β2γ1:1.1 µM, AMPK α2β1γ1:0.95 μM (EC50)
In vitro	ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). It increases the activity of α1β1γ1 by 1.5-fold with an EC50 of 0.42 μM, α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM, recombinant AMPK α1β2γ1 by 1.7-fold with an EC50 of 1.1 μM, and AMPK α2β2γ1 by 1.6-fold with an EC50 of 0.13 μM.
In vivo	C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. After 4 weeks of treatment, ZLN024 improves glucose tolerance, reduces fasting blood glucose by 15%, and decreases liver tissue weight, triacylglycerol, and total cholesterol content.

Chemical Properties

Molecular Weight	325.22
Formula	C₁₃H₁₃BrN₂OS
Cas No.	723249-01-2
Smiles	Cc1ccc(OCCSc2ncccn2)c(Br)c1
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (153.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0748 mL	15.3742 mL	30.7484 mL	153.7421 mL
5 mM	0.6150 mL	3.0748 mL	6.1497 mL	30.7484 mL
10 mM	0.3075 mL	1.5374 mL	3.0748 mL	15.3742 mL
20 mM	0.1537 mL	0.7687 mL	1.5374 mL	7.6871 mL
50 mM	0.0615 mL	0.3075 mL	0.6150 mL	3.0748 mL
100 mM	0.0307 mL	0.1537 mL	0.3075 mL	1.5374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc