Powder: -20°C for 3 years | In solvent: -80°C for 1 year
nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM. It demonstrates metabolic stability in liver microsomes and possesses a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM. It demonstrates metabolic stability in liver microsomes and possesses a favorable brain-to-plasma ratio, indicating effective oral bioavailability. This compound is utilized in nervous system disease research [1]. |
In vitro | Compound 11j (nSMase2-IN-1) at a concentration of 5μM has demonstrated good metabolic stability in rat liver microsomes, with 95% remaining after a 60-minute incubation period [1]. |
In vivo | nSMase2-IN-1 (Compound 11j), administered orally at a dose of 10 mg/kg and samples taken for analysis 30 minutes and 2 hours post-dosing, demonstrated efficacy and brain penetration in male Wistar rats [1]. |
Molecular Weight | 247.3 |
Formula | C12H17N5O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
nSMase2-IN-1 Metabolism Phospholipase inhibitor inhibit