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Nordihydroguaiaretic acid

Name: Nordihydroguaiaretic acid
Brand: TargetMol
SKU: TJS2190
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJS2190Cas No. 500-38-9

Alias NDGA, Dihydronorguaiaretic Acid

Nordihydroguaiaretic acid (NDGA) is a natural product, extracted from Pole Fork Kelaroa, and is a lipoxygenase (5-LOX) inhibitor (IC50=8 μM). Nordihydroguaiaretic acid possesses antioxidant and free radical scavenging properties.

Nordihydroguaiaretic acid

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Purity: 99.91%

Catalog No. TJS2190Alias NDGA, Dihydronorguaiaretic AcidCas No. 500-38-9

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$45	-	In Stock
500 mg	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Nordihydroguaiaretic acid (NDGA) is a natural product, extracted from Pole Fork Kelaroa, and is a lipoxygenase (5-LOX) inhibitor (IC50=8 μM). Nordihydroguaiaretic acid possesses antioxidant and free radical scavenging properties.
Targets&IC50	P388 cells apoptosis:0.66 μg/mL, SKBR3 cells proliferation:31.09 ± 1.6 μM, MDA-MB-435 cells proliferation:38.8 ± 2.1 μM, 5-LOX:8 ± 3 μM
In vitro	METHODS: Voxelotor (3-30 µmol/L) was incubated with hemoglobin (25 µmol/L) in TES or saline buffer at 37 ℃ for 45 min, and changes in the binding affinity of O2 for Hb were measured using a TCS hematology analyzer. RESULTS: Voxelotor, a small molecule that binds to the N-terminal α-chain of Hb, increases the affinity of HbS for oxygen, delays HbS polymerization in vitro and prevents erythrocyte sickling. [1] METHODS: HepG2 cells were treated with Voxelotor (1 µg/mL) and their metabolites were analyzed by liquid chromatography, high resolution MS and tandem MS. RESULTS: Voxelotor can be used for the identification of phase I and phase II metabolites in vitro. [2]
In vivo	METHODS: To assess the activity and efficacy of Voxelotor, Voxelotor (100-150 mg/kg, 0.5% methylcellulose/0.5% SDS) was administered by gavage to a mouse model of SCD twice daily for 9-12 days. RESULTS: Voxelotor reduced isolated sickle cells and prolonged erythrocyte half-life in the SCD mouse model. [1]
Synonyms	NDGA, Dihydronorguaiaretic Acid

Chemical Properties

Molecular Weight	302.36
Formula	C₁₈H₂₂O₄
Cas No.	500-38-9
Smiles	CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Relative Density.	1.0772 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43 mg/mL (142.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 4.3 mg/mL (14.22 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3073 mL	16.5366 mL	33.0732 mL	165.3658 mL
5 mM	0.6615 mL	3.3073 mL	6.6146 mL	33.0732 mL
10 mM	0.3307 mL	1.6537 mL	3.3073 mL	16.5366 mL
20 mM	0.1654 mL	0.8268 mL	1.6537 mL	8.2683 mL
50 mM	0.0661 mL	0.3307 mL	0.6615 mL	3.3073 mL
100 mM	0.0331 mL	0.1654 mL	0.3307 mL	1.6537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc