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Minocycline

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Catalog No. T131626Cas No. 10118-90-8

Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.

Minocycline
Other Forms of Minocycline:

Minocycline

😃Good
Catalog No. T131626Cas No. 10118-90-8
Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
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5 mg$899-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
In vitro
Ovarian cancer cell lines (OVCAR-3, SKOV-3, and A2780) were treated with minocycline (0-100 μM, 24-72 hours) to observe its effect on cell proliferation. Results: Minocycline inhibited the proliferation and colony formation activity of OVCAR-3, SKOV-3, and A2780 cells. [1]
In vivo
Methods: Minocycline (0-30 mg/kg, orally, once daily for 4 weeks) was used to treat female nude mice bearing OVCAR-3 tumor xenografts to investigate its inhibitory effect on tumors in mice. Results: Minocycline inhibited the growth of OVCAR-3 tumors in female nude mice. [1]
Chemical Properties
Molecular Weight457.48
FormulaC23H27N3O7
Cas No.10118-90-8
SmilesO[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=CC4O)[H])[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (43.72 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2 mg/mL (4.37 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1859 mL10.9294 mL21.8589 mL109.2944 mL
5 mM0.4372 mL2.1859 mL4.3718 mL21.8589 mL
10 mM0.2186 mL1.0929 mL2.1859 mL10.9294 mL
20 mM0.1093 mL0.5465 mL1.0929 mL5.4647 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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