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Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
Pack Size | Price | Availability | Quantity |
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1 mg | Inquiry | Backorder | |
5 mg | Inquiry | In Stock |
Description | Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects. |
In vitro | Ovarian cancer cell lines (OVCAR-3, SKOV-3, and A2780) were treated with minocycline (0-100 μM, 24-72 hours) to observe its effect on cell proliferation. Results: Minocycline inhibited the proliferation and colony formation activity of OVCAR-3, SKOV-3, and A2780 cells. [1] |
In vivo | Methods: Minocycline (0-30 mg/kg, orally, once daily for 4 weeks) was used to treat female nude mice bearing OVCAR-3 tumor xenografts to investigate its inhibitory effect on tumors in mice. Results: Minocycline inhibited the growth of OVCAR-3 tumors in female nude mice. [1] |
Molecular Weight | 457.48 |
Formula | C23H27N3O7 |
Cas No. | 10118-90-8 |
Smiles | O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=CC4O)[H])[H] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
Solubility Information | DMSO: 20.00 mg/mL (43.72 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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