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Minocycline

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Catalog No. T131626Cas No. 10118-90-8

Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.

Minocycline
Other Forms of Minocycline:
Minocycline hydrochlorideT110113614-98-7
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Minocycline

😃Good
Catalog No. T131626Cas No. 10118-90-8
Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
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Product Introduction

Bioactivity
Description
Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
In vitro
Ovarian cancer cell lines (OVCAR-3, SKOV-3, and A2780) were treated with minocycline (0-100 μM, 24-72 hours) to observe its effect on cell proliferation. Results: Minocycline inhibited the proliferation and colony formation activity of OVCAR-3, SKOV-3, and A2780 cells. [1]
In vivo
Methods: Minocycline (0-30 mg/kg, orally, once daily for 4 weeks) was used to treat female nude mice bearing OVCAR-3 tumor xenografts to investigate its inhibitory effect on tumors in mice. Results: Minocycline inhibited the growth of OVCAR-3 tumors in female nude mice. [1]
Chemical Properties
Molecular Weight457.48
FormulaC23H27N3O7
Cas No.10118-90-8
SmilesO[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=CC4O)[H])[H]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20.00 mg/mL (43.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1859 mL10.9294 mL21.8589 mL109.2944 mL
5 mM0.4372 mL2.1859 mL4.3718 mL21.8589 mL
10 mM0.2186 mL1.0929 mL2.1859 mL10.9294 mL
20 mM0.1093 mL0.5465 mL1.0929 mL5.4647 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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