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Metabolism

ATP Citrate Lyase

(11)

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(30)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(30)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(76)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(47)

Stearoyl-CoA Desaturase (SCD)

NADPH

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent. It is used by all forms of cellular life.NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase.

Filter Signaling PathwaysMetabolismNADPH

Resveratrol
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
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Metronidazole
T1079443-48-1
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
- $30
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KL1333
T163421800405-30-4
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
- $95
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Setanaxib
T60991218942-37-0
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
- $34
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Diphenyleneiodonium chloride
T71914673-26-1
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
- $38
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GSK2795039
T154331415925-18-6
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
- $67
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S29434
T7149874484-20-5
S29434 (NMDPEF) is a potent, competitive inhibitor of quinone reductase 2 (QR2), with an IC50 range of 5-16 nM.
- $51
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Triclosan
T13143380-34-5
Triclosan (Irgasan) is an antibacterial and antifungal agent.
- $41
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AKR1C1-IN-1
T141514906-68-7
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
- $38
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Apocynin
T6391498-02-2
Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
- $50
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Carvedilol phosphate hemihydrate
T0342610309-89-2
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and no intrinsic sympathomimetic activity.
- $31
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Quercetin-3-O-glucose-6''-acetate
TN212654542-51-7
Quercetin-3-O-glucose-6''-acetate (6 -O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.
- $106
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Dicoumarol
T080966-76-2
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
- $41
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VAS2870
T4359722456-31-7
VAS2870 is an inhibitor of NADPH oxidase (NOX).
- $52
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2-HBA
T7374131359-24-5
2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
- $37
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HTS07545
T61316118666-03-8
HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.
- $38
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AKR1C3-IN-1
T7406327092-81-9
AKR1C3-IN-1 is a potent and selective inhibitor of AKR1C3(IC50 of 13 nM).
- $31
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Pasiniazid
T04412066-89-9
Pasiniazid (Paraniazide) is an anti-TB and anti-leprosy drug.
- $42
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GLX351322
T8107835598-94-2
GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
- $42
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APX-115 free base
T103531270084-92-8
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.
- $29
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GKT136901
T8408955272-06-7
GKT136901 (AK120765) is an inhibitor of NOX1 4.It acts as Selective and Direct Scavenger of Peroxynitrite
- $37
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AKR1C3-IN-4
T386841284180-11-5
AKR1C3-IN-4, a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3) with an IC50 of 0.56 μM, shows potential for castrate-resistant prostate cancer (CRPC) research.
- $30
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Acetohexamide
T0816968-81-0
Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
- $29
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ASP-9521
T45291126084-37-4
ASP-9521 is a selective, potent and orally active indole-based AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.
- $33
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NQO1 substrate
T137992304503-05-5
NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.
- $38
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Casein kinase 1δ-IN-9
T64376854355-54-7
Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.
- $88
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Obafistat
T396352160582-57-8
Obafistat is a potent inhibitor of aldo-keto reductase AKR1C3 with an IC50 of 1.2 nM for human AKR1C3.
- $33
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AKR1C3-IN-9
T67846
AKR1C3-IN-9, a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50 = 8.92 nM), can significantly reverse Doxorubicin (DOX) resistance in a resistant breast cancer cell line.
- $38
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S19-1035
T67950
S19-1035 is a potent and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3), displaying an inhibitory concentration (IC50) of 3.04 nM. It is primarily utilized in tumor research.
- $55
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GSK2194069
T154291332331-08-4
GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH.
- $149
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Dehydroglyasperin C
TN3806199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases
- $871
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Nucleocidin
T1636124751-69-7
Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.
- $1,520
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