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Syk Inhibitor II

Name: Syk Inhibitor II
Brand: TargetMol
SKU: T4348
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4348Cas No. 726695-51-8

Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).

Syk Inhibitor II

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Purity: 97.63%

Catalog No. T4348Cas No. 726695-51-8

Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$40	-	In Stock
1 mL x 10 mM (in DMSO)	$86	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.63%

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Product Introduction

Bioactivity

Description	Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
Targets&IC50	ZAP70:11.2 μM, Syk:41 nM, ITK:22.6 μM, PKCε:5.1 μM, 5-HT:460 nM, BTK:15.5 μM, PKCβ2:11 μM
In vitro	In mice,Syk inhibitor II prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions (ID50 = 13.2 mg/kg, s.c.).

Chemical Properties

Molecular Weight	340.3
Formula	C₁₄H₁₅F₃N₆O
Cas No.	726695-51-8
Smiles	NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Relative Density.	1.455 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (293.86 mM), Sonication is recommended.

H2O: 25 mg/mL (73.46 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9386 mL	14.6929 mL	29.3858 mL	146.9292 mL
5 mM	0.5877 mL	2.9386 mL	5.8772 mL	29.3858 mL
10 mM	0.2939 mL	1.4693 mL	2.9386 mL	14.6929 mL
20 mM	0.1469 mL	0.7346 mL	1.4693 mL	7.3465 mL
50 mM	0.0588 mL	0.2939 mL	0.5877 mL	2.9386 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	1.4693 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc