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1-Dodecylimidazole

Name: 1-Dodecylimidazole
Brand: TargetMol
SKU: T37885
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37885Cas No. 4303-67-7

1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.

1-Dodecylimidazole

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Purity: 97.01%

Catalog No. T37885Cas No. 4303-67-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
2 g	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.01%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.
In vitro	1-Dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. 1-Dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4].
In vivo	The hypocholesterolaemic activity of 1-dodecylimidazole partly arises from inhibiting cholesterol biosynthesis at the 2,3-oxidosqualene sterol cyclase level[2]. Administration of 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) results in lower serum cholesterol concentrations compared to control rats[2].

Chemical Properties

Molecular Weight	236.4
Formula	C₁₅H₂₈N₂
Cas No.	4303-67-7
Smiles	CCCCCCCCCCCCn1ccnc1
Relative Density.	0.9624 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (423.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (13.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2301 mL	21.1506 mL	42.3012 mL	211.5059 mL
5 mM	0.8460 mL	4.2301 mL	8.4602 mL	42.3012 mL
10 mM	0.4230 mL	2.1151 mL	4.2301 mL	21.1506 mL
20 mM	0.2115 mL	1.0575 mL	2.1151 mL	10.5753 mL
50 mM	0.0846 mL	0.4230 mL	0.8460 mL	4.2301 mL
100 mM	0.0423 mL	0.2115 mL	0.4230 mL	2.1151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc