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1-Dodecylimidazole

Name: 1-Dodecylimidazole
Brand: TargetMol
SKU: T37885
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37885Cas No. 4303-67-7

1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.

1-Dodecylimidazole

🥰Excellent

Purity: 97.01%

Catalog No. T37885Cas No. 4303-67-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
2 g	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.01%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that acts as a cytotoxic agent and lysosomotropic detergent, inducing cell death through acid-dependent lysosomal accumulation, disrupting the lysosomal membrane, and releasing cysteine proteases into the cytoplasm. It also exhibits hypocholesterolemic and broad-spectrum antifungal activities.
In vitro	1-Dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. 1-Dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4].
In vivo	The hypocholesterolaemic activity of 1-dodecylimidazole partly arises from inhibiting cholesterol biosynthesis at the 2,3-oxidosqualene sterol cyclase level[2]. Administration of 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) results in lower serum cholesterol concentrations compared to control rats[2].

Chemical Properties

Molecular Weight	236.4
Formula	C₁₅H₂₈N₂
Cas No.	4303-67-7
Smiles	CCCCCCCCCCCCn1ccnc1
Relative Density.	0.9624 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (423.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (13.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2301 mL	21.1506 mL	42.3012 mL	211.5059 mL
5 mM	0.8460 mL	4.2301 mL	8.4602 mL	42.3012 mL
10 mM	0.4230 mL	2.1151 mL	4.2301 mL	21.1506 mL
20 mM	0.2115 mL	1.0575 mL	2.1151 mL	10.5753 mL
50 mM	0.0846 mL	0.4230 mL	0.8460 mL	4.2301 mL
100 mM	0.0423 mL	0.2115 mL	0.4230 mL	2.1151 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc