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Tapinarof

Name: Tapinarof
Brand: TargetMol
SKU: T4644
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4644Cas No. 79338-84-4

Alias WBI 1001, GSK2894512, Benvitimod

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

Tapinarof

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Purity: 99.98%

Catalog No. T4644Alias WBI 1001, GSK2894512, BenvitimodCas No. 79338-84-4

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$61	In Stock	In Stock
25 mg	$121	In Stock	In Stock
50 mg	$188	In Stock	In Stock
100 mg	$312	In Stock	In Stock
200 mg	$538	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
Targets&IC50	AhR:13 nM（EC50）
In vitro	Tapinarof activates the AhR pathway through direct binding, inducing dose-dependent nuclear translocation of AhR in immortalized keratinocytes (HaCaT).
In vivo	Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice.
Synonyms	WBI 1001, GSK2894512, Benvitimod

Chemical Properties

Molecular Weight	254.32
Formula	C₁₇H₁₈O₂
Cas No.	79338-84-4
Smiles	CC(C)c1c(O)cc(\C=C\c2ccccc2)cc1O
Relative Density.	1.158 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (216.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL	196.6027 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
20 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8301 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc