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Tapinarof

Name: Tapinarof
Brand: TargetMol
SKU: T4644
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4644Cas No. 79338-84-4

Alias WBI 1001, GSK2894512, Benvitimod

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

Tapinarof

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Purity: 99.64%

Catalog No. T4644Alias WBI 1001, GSK2894512, BenvitimodCas No. 79338-84-4

Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$61	In Stock	In Stock
25 mg	$121	In Stock	In Stock
50 mg	$188	In Stock	In Stock
100 mg	$312	In Stock	In Stock
200 mg	$538	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
Targets&IC50	AhR:13 nM（EC50）
In vitro	Tapinarof activates the AhR pathway through direct binding, inducing dose-dependent nuclear translocation of AhR in immortalized keratinocytes (HaCaT).
In vivo	Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice.
Synonyms	WBI 1001, GSK2894512, Benvitimod

Chemical Properties

Molecular Weight	254.32
Formula	C₁₇H₁₈O₂
Cas No.	79338-84-4
Smiles	CC(C)c1c(O)cc(\C=C\c2ccccc2)cc1O
Relative Density.	1.158 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (216.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL	196.6027 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
20 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8301 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc