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Anti-Phospho-Gria2 (Ser880) Polyclonal Antibody 2
🥰Excellent
Catalog No. TMAB-10752
Antibody Type: Rabbit Polyclonal
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human,Mouse,Rat (predicted:Chicken,Cow,Horse)
Anti-Phospho-Gria2 (Ser880) Polyclonal Antibody 2
Anti-Phospho-Gria2 (Ser880) Polyclonal Antibody 2
🥰Excellent
Catalog No. TMAB-10752
Antibody Type: Rabbit Polyclonal
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human,Mouse,Rat (predicted:Chicken,Cow,Horse)
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human,Mouse,Rat (predicted:Chicken,Cow,Horse)
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Gria2 (Ser880) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Gria2 (Ser880). Anti-Phospho-Gria2 (Ser880) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Gria2 around the phosphorylation site of Ser880 |
| Antigen Species | Human |
| Gene Name | GRIA2 |
| Gene ID | |
| Protein Name | Glutamate receptor 2 |
| Uniprot ID | |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Molecular Weight | Theoretical: 96 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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