Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

GDC-0834 Racemate

Name: GDC-0834 Racemate
Brand: TargetMol
SKU: T11378L
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T11378LCas No. 1133432-46-8

GDC-0834 (racemate) is the racemate form of GDC-0834, an effective and selective BTK inhibitor.

GDC-0834 Racemate

Copy Product Info

😃Good

Catalog No. T11378LCas No. 1133432-46-8

GDC-0834 (racemate) is the racemate form of GDC-0834, an effective and selective BTK inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$98	5 days	5 days
5 mg	$214	5 days	5 days
50 mg	$723	6-8 weeks	6-8 weeks
100 mg	$996	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	GDC-0834 (racemate) is the racemate form of GDC-0834, an effective and selective BTK inhibitor.
In vitro	GDC-0834 inhibited BTK (IC50s: 5.9 and 6.4 nM in biochemical and cellular assays) and (IC50s: 1.1 and 5.6 μM in mouse and rat) [1].
In vivo	Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2].

Chemical Properties

Molecular Weight	596.74
Formula	C₃₃H₃₆N₆O₃S
Cas No.	1133432-46-8
Smiles	CN1CCN(C)C(=O)C1c1ccc(Nc2nc(cn(C)c2=O)-c2cccc(NC(=O)c3cc4CCCCc4s3)c2C)cc1
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49 mg/mL (82.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6758 mL	8.3789 mL	16.7577 mL	83.7886 mL
5 mM	0.3352 mL	1.6758 mL	3.3515 mL	16.7577 mL
10 mM	0.1676 mL	0.8379 mL	1.6758 mL	8.3789 mL
20 mM	0.0838 mL	0.4189 mL	0.8379 mL	4.1894 mL
50 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6758 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc