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Bambuterol hydrochloride

Name: Bambuterol hydrochloride
Brand: TargetMol
SKU: T1446
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1446Cas No. 81732-46-9

Alias KWD-2183 hydrochloride, Bambuterol HCl, (±)-Bambuterol hydrochloride

Bambuterol hydrochloride (KWD-2183 hydrochloride) , a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.

Bambuterol hydrochloride

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Purity: 99.61%

Catalog No. T1446Alias KWD-2183 hydrochloride, Bambuterol HCl, (±)-Bambuterol hydrochlorideCas No. 81732-46-9

Bambuterol hydrochloride (KWD-2183 hydrochloride) , a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$63	In Stock	In Stock
50 mg	$80	In Stock	In Stock
100 mg	$98	In Stock	In Stock
200 mg	$135	In Stock	In Stock
500 mg	$223	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bambuterol hydrochloride AI Summary

Bambuterol hydrochloride is a bioactive molecule exhibiting a range of inhibitory properties. It moderately inhibits lipid storage modulators in Drosophila S3 cells, AmpC Beta-Lactamase, and the ERG Ets/DNA interaction. It also demonstrates significant potency in modulating lipid storage and strongly inhibits HP1-beta chromodomain interactions with methylated histone tails. Additionally, it shows moderate potency against human tyrosyl-DNA phosphodiesterase 1 (TDP1), acts as an antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2), and inhibits USP1/UAF1 interactions. Moreover, Bambuterol hydrochloride has activity against Ebola virus entry in different screening assays with varying potency levels. In the context of antiviral activities, Bambuterol hydrochloride shows low cytotoxicity and efficacy in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at a low multiplicity of infection (MOI) after 72 hours. It exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours of viral exposure, indicating inhibition percentages of -1.07% and 0.12%, respectively. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 10.58% at a concentration of 20µM, as determined by a FRET-based assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bambuterol hydrochloride (KWD-2183 hydrochloride) , a long-acting beta-adrenoceptor agonist, is utilized for the treating of asthma.
Synonyms	KWD-2183 hydrochloride, Bambuterol HCl, (±)-Bambuterol hydrochloride

Chemical Properties

Molecular Weight	403.91
Formula	C₁₈H₃₀ClN₃O₅
Cas No.	81732-46-9
Smiles	c1(cc(cc(c1)C(CNC(C)(C)C)O)OC(=O)N(C)C)OC(=O)N(C)C.Cl
Relative Density.	1.154g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (123.79 mM), Sonication is recommended.

H2O: 66 mg/mL (163.4 mM), Sonication is recommended.

Ethanol: 8 mg/mL (19.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4758 mL	12.3790 mL	24.7580 mL	123.7900 mL
5 mM	0.4952 mL	2.4758 mL	4.9516 mL	24.7580 mL
10 mM	0.2476 mL	1.2379 mL	2.4758 mL	12.3790 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
20 mM	0.1238 mL	0.6189 mL	1.2379 mL	6.1895 mL
50 mM	0.0495 mL	0.2476 mL	0.4952 mL	2.4758 mL
100 mM	0.0248 mL	0.1238 mL	0.2476 mL	1.2379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc