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2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine
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Catalog No. TNU0168Cas No. 103884-98-6
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis. The anticancer mechanism of 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is dependent on the inhibition of DNA synthesis.
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine
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Purity: 98.06%
Catalog No. TNU0168Cas No. 103884-98-6
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis. The anticancer mechanism of 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is dependent on the inhibition of DNA synthesis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | - | In Stock | |
| 5 mg | $82 | - | In Stock | |
| 10 mg | $122 | - | In Stock | |
| 25 mg | $221 | - | In Stock | |
| 50 mg | $320 | - | In Stock | |
| 100 mg | $449 | - | In Stock | |
| 200 mg | $603 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.06%
Appearance:Solid
Color:Yellow
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Product Introduction
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine AI Summary
2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine displays potent antiviral activity against multiple viruses, including HSV-1, HSV-2, and the Influenza virus (H1N1), with varying inhibitory concentrations. For HSV-1 strain KOS, the IC50 is 5.0 µg/ml, and for HSV-2 strain 186, it is 19.0 µg/ml, as assessed by plaque reduction assay. The compound also effectively inhibits macromolecular synthesis and demonstrates varying degrees of cytotoxicity across different cell lines. In L1210 cells, it inhibits DNA synthesis with inhibition levels between 12.0% and 76.0% and protein synthesis by 17.0%. In MDCK cells, the IC50 for antiviral activity against Influenza H1N1 is 19000.0 nM, while it has a cytotoxicity IC50 of 440000.0 nM. Against HBV in HepG2 2.2.15 cells, the compound shows an EC50 greater than 10000.0 nM but exhibits high cytotoxicity with IC50 values greater than 200000.0 nM in HepG2 2.2.15 cells and greater than 100000.0 nM in CEM cells. Furthermore, the compound shows low cytotoxicity with an inhibitory concentration greater than 100.0 µg/ml in vero cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis. The anticancer mechanism of 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is dependent on the inhibition of DNA synthesis. |
| Molecular Weight | 285.23 |
| Formula | C10H12FN5O4 |
| Cas No. | 103884-98-6 |
| Smiles | O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)NC(N)=N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (175.3 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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