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Gap19

Name: Gap19
Brand: TargetMol
SKU: TP1563
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1563Cas No. 1507930-57-5

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.

Gap19

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Purity: 97.67%

Catalog No. TP1563Cas No. 1507930-57-5

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$235	In Stock	In Stock
50 mg	$375	In Stock	In Stock
100 mg	$552	In Stock	In Stock
200 mg	$787	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.67%

Appearance:solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.

In vitro

Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo[2].

Chemical Properties

Molecular Weight	1161.44
Formula	C₅₅H₉₆N₁₄O₁₃
Cas No.	1507930-57-5
Smiles	[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@@H](CCCCN)C(O)=O)=O
Relative Density.	1.212 g/cm3 (Predicted)
Sequence	{Lys}{Gln}{Ile}{Glu}{Ile}{Lys}{Lys}{Phe}{Lys}
Sequence Short	KQIEIKKFK

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (215.25 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.8610 mL	4.3050 mL	8.6100 mL	43.0500 mL
5 mM	0.1722 mL	0.8610 mL	1.7220 mL	8.6100 mL
10 mM	0.0861 mL	0.4305 mL	0.8610 mL	4.3050 mL
20 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1525 mL
50 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.8610 mL
100 mM	0.0086 mL	0.0431 mL	0.0861 mL	0.4305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc