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Gap19
🥰Excellent
Catalog No. TP1563Cas No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
Gap19
🥰Excellent
Purity: 97.67%
Catalog No. TP1563Cas No. 1507930-57-5
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $40 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $143 | In Stock | |
| 25 mg | $235 | In Stock | |
| 50 mg | $375 | In Stock | |
| 100 mg | $552 | In Stock | |
| 200 mg | $787 | In Stock |
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Purity:97.67%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43. |
| In vitro | Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo[2]. |
| Molecular Weight | 1161.44 |
| Formula | C55H96N14O13 |
| Cas No. | 1507930-57-5 |
| Smiles | [C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@@H](CCCCN)C(O)=O)=O |
| Relative Density. | 1.212 g/cm3 (Predicted) |
| Sequence | {Lys}{Gln}{Ile}{Glu}{Ile}{Lys}{Lys}{Phe}{Lys} |
| Sequence Short | KQIEIKKFK |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 5 mM, Sonication is recommended. DMSO: Insoluble | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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