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Niga-ichigoside F1

🥰Excellent
Catalog No. TN1989Cas No. 95262-48-9

Niga-ichigoside F1 is a natural product that activates Nrf2 and improves high-fat diet-induced hepatic steatosis in male mice, while also inhibiting the NF-κB pathway to alleviate DSS-induced ulcerative colitis.

Niga-ichigoside F1

Niga-ichigoside F1

🥰Excellent
Purity: 99.97%
Catalog No. TN1989Cas No. 95262-48-9
Niga-ichigoside F1 is a natural product that activates Nrf2 and improves high-fat diet-induced hepatic steatosis in male mice, while also inhibiting the NF-κB pathway to alleviate DSS-induced ulcerative colitis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$71-In Stock
5 mg$172-In Stock
10 mg$278-In Stock
25 mg$473-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.97%
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Product Introduction

Bioactivity
Description
Niga-ichigoside F1 is a natural product that activates Nrf2 and improves high-fat diet-induced hepatic steatosis in male mice, while also inhibiting the NF-κB pathway to alleviate DSS-induced ulcerative colitis.
In vitro
Niga-ichigoside F1 (2.5, 5, 10, and 20 μM, 24 hours) dose-dependently inhibited lipid accumulation in free fatty acid (FFA)-treated HepG2 cells, with no significant effect on cell viability [1].
In the control group, Niga-ichigoside F1 (20 μM)-treated group, free fatty acid (1 mM)-treated group, and Niga-ichigoside F1 combined with free fatty acid-treated Nrf2-silenced cells, the expression levels of Nrf2 in both the nucleus and cytoplasm were downregulated [1].
Chemical Properties
Molecular Weight666.85
FormulaC36H58O11
Cas No.95262-48-9
SmilesC(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]23[C@](C=4[C@@](C)(CC2)[C@@]5(C)[C@](CC4)([C@]6(C)[C@@](CC5)([C@@](CO)(C)[C@@H](O)[C@H](O)C6)[H])[H])([C@](C)(O)[C@H](C)CC3)[H]
Relative Density.1.35 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40.00 mg/mL (59.98 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4996 mL7.4979 mL14.9959 mL74.9794 mL
5 mM0.2999 mL1.4996 mL2.9992 mL14.9959 mL
10 mM0.1500 mL0.7498 mL1.4996 mL7.4979 mL
20 mM0.0750 mL0.3749 mL0.7498 mL3.7490 mL
50 mM0.0300 mL0.1500 mL0.2999 mL1.4996 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Nrf2NO SynthaseNiga-ichigoside F-1Niga-ichigoside F1Nigaichigoside F1Niga ichigoside F1
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