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Niga-ichigoside F1

Name: Niga-ichigoside F1
Brand: TargetMol
SKU: TN1989
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1989Cas No. 95262-48-9

Niga-ichigoside F1 is a natural product that activates Nrf2 and improves high-fat diet-induced hepatic steatosis in male mice, while also inhibiting the NF-κB pathway to alleviate DSS-induced ulcerative colitis.

Niga-ichigoside F1

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Purity: 99.97%

Catalog No. TN1989Cas No. 95262-48-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$172	-	In Stock
10 mg	$278	-	In Stock
25 mg	$473	-	In Stock
50 mg	$693	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Niga-ichigoside F1 (2.5, 5, 10, and 20 μM, 24 hours) dose-dependently inhibited lipid accumulation in free fatty acid (FFA)-treated HepG2 cells, with no significant effect on cell viability [1].
In the control group, Niga-ichigoside F1 (20 μM)-treated group, free fatty acid (1 mM)-treated group, and Niga-ichigoside F1 combined with free fatty acid-treated Nrf2-silenced cells, the expression levels of Nrf2 in both the nucleus and cytoplasm were downregulated [1].

Chemical Properties

Molecular Weight	666.85
Formula	C₃₆H₅₈O₁₁
Cas No.	95262-48-9
Smiles	C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)(=O)[C@]23[C@](C=4[C@@](C)(CC2)[C@@]5(C)[C@](CC4)([C@]6(C)[C@@](CC5)([C@@](CO)(C)[C@@H](O)[C@H](O)C6)[H])[H])([C@](C)(O)[C@H](C)CC3)[H]
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (59.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4996 mL	7.4979 mL	14.9959 mL	74.9794 mL
5 mM	0.2999 mL	1.4996 mL	2.9992 mL	14.9959 mL
10 mM	0.1500 mL	0.7498 mL	1.4996 mL	7.4979 mL
20 mM	0.0750 mL	0.3749 mL	0.7498 mL	3.7490 mL
50 mM	0.0300 mL	0.1500 mL	0.2999 mL	1.4996 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc