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Anti-Phospho-MLKL (Ser345) Polyclonal Antibody
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Catalog No. TMAB-11000
Anti-Phospho-MLKL (Ser345) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MLKL (Ser345). Anti-Phospho-MLKL (Ser345) Polyclonal Antibody can be used in WB.
Anti-Phospho-MLKL (Ser345) Polyclonal Antibody
Anti-Phospho-MLKL (Ser345) Polyclonal Antibody
😃Good
Catalog No. TMAB-11000
Anti-Phospho-MLKL (Ser345) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MLKL (Ser345). Anti-Phospho-MLKL (Ser345) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MLKL (Ser345) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MLKL (Ser345). Anti-Phospho-MLKL (Ser345) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Lyophilized or Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: mouse MLKL around the phosphorylation site of Ser345 |
| Antigen Species | Mouse |
| Gene Name | MLKL |
| Gene ID | |
| Protein Name | Mixed lineage kinase domain-like protein |
| Uniprot ID | |
| Function | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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