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Permethrin

Name: Permethrin
Brand: TargetMol
SKU: T1332
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1332Cas No. 52645-53-1

Alias Transpermethrin, Pounce, NRDC-143, Ambush

Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.

Permethrin

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Purity: 99.54%

Catalog No. T1332Alias Transpermethrin, Pounce, NRDC-143, AmbushCas No. 52645-53-1

Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$29	In Stock	In Stock
500 mg	$69	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Color:White

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COA HPLC HNMR

Product Introduction

Permethrin AI Summary

Permethrin exhibits a wide spectrum of bioactivities with significant parasiticidal, insecticidal, and antifeedant properties. It demonstrates potent parasiticidal activity against Rhipicephalus sanguineus with an LD50 of 0.14 µg per tick and shows strong insecticidal effects against various insect species such as Periplaneta americana, Ascia monuste orseis, Sitophilus zeamais, and Acanthoscelides obtectus, with mortality rates ranging from 17.5% to 100%. The compound also inhibits feeding in Tineola bisselliella and Anthrenocerus australis larvae at a concentration of 0.01% w/w, leading to substantial wool weight loss. In assays, it exhibits mosquito larvicidal activity against Culex quinquefasciatus with LC50 values of 0.005 ppm and 0.16 ppm for susceptible and resistant strains, respectively. Permethrin shows a high lipophilicity with a log P value of 7.38, indicating a strong affinity for lipid environments. It also has a high octanol-water partition coefficient (log KOW = 6.1), suggesting potential for bioaccumulation in aquatic environments. The compound is active in a variety of receptor and enzyme interactions, displaying both agonist and antagonist activities and interacting with receptors such as HRH2, BDKRB2, GHSR, and AGTR1. It is also effective against first-instar larvae of Cheumatopsyche brevilineata and Daphnia magna, with higher toxicity toward the former. However, it exhibits no bioactivity related to liver injury or hepatic side effects based on DILIps assessments, with HepSE scores reported as 0.0. While strong contact toxicity is observed against adult Tetragonisca angustula, adult Solenopsis saevissima, and second-instar larvae of Tuta absoluta, the compound demonstrates high selectivity for particular pest control strategies. In therapeutic contexts, Permethrin shows promise in various biochemical pathways, indicating potential as a treatment for conditions such as Ataxia-Telangiectasia. Its potency ranges from 1.4 nM to above 420,000 nM in diverse bioassays, including those targeting Lamin A splicing, TDP1, histone lysine methyltransferases, and others. It also impacts liver enzyme activity, increasing levels of composite activity markers like SGOT, SGPT, and LDH. Overall, Permethrin is a versatile agent with significant bioactivity across multiple domains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Synonyms	Transpermethrin, Pounce, NRDC-143, Ambush

Chemical Properties

Molecular Weight	391.29
Formula	C₂₁H₂₀Cl₂O₃
Cas No.	52645-53-1
Smiles	CC1(C)[C@@H](C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1
Relative Density.	1.19

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (638.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5556 mL	12.7782 mL	25.5565 mL	127.7825 mL
5 mM	0.5111 mL	2.5556 mL	5.1113 mL	25.5565 mL
10 mM	0.2556 mL	1.2778 mL	2.5556 mL	12.7782 mL
20 mM	0.1278 mL	0.6389 mL	1.2778 mL	6.3891 mL
50 mM	0.0511 mL	0.2556 mL	0.5111 mL	2.5556 mL
100 mM	0.0256 mL	0.1278 mL	0.2556 mL	1.2778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc