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Sulopenem

Name: Sulopenem
Brand: TargetMol
SKU: T22433
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22433Cas No. 120788-07-0

Alias CP-70429, CP70429

Sulopenem (CP-70429) is an orally active gastrointestinal-external cephalosporin antibiotic with broad-spectrum antibacterial activity. It inhibits Gram-positive and Gram-negative bacteria and can be used in bacterial infection research.

Sulopenem

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Purity: 99.38%

Catalog No. T22433Alias CP-70429, CP70429Cas No. 120788-07-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	-	In Stock
5 mg	$330	-	In Stock
10 mg	$538	-	In Stock
25 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$363	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.38%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sulopenem (CP-70429) is an orally active gastrointestinal-external cephalosporin antibiotic with broad-spectrum antibacterial activity. It inhibits Gram-positive and Gram-negative bacteria and can be used in bacterial infection research.
Targets&IC50	E. coli:0.015-0.12 µg/mL (MIC)
In vitro	Sulopenem exhibits potential for the treatment of simple and complicated urinary tract infections and intra-abdominal infections, especially for multi-drug resistant (MDR) infections and infections caused by quinolone-ineffective and/or broad-spectrum beta-lactamase-producing (ESBL) gram-negative bacilli. [1] Sulopenem inhibits the growth of most aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-sensitive Staphylococcus aureus, Streptococcus pneumoniae (including penicillin-sensitive and resistant strains), group A and B beta-hemolytic streptococci, Listeria monocytogenes, Enterobacteriaceae, Haemophilus influenzae, and Catamorpha but is ineffective against Pseudomonas aeruginosa and Stenotrophomonas maltophilia. Aeromonas, and its inhibitory activity is evident at concentrations ≤1 μg/mL. [1]
In vivo	In a mouse model of experimental systemic infection, Sulopenem was superior to imipenem/cilastatin in terms of protective capacity. Sulopenem showed lower ED50 values in mice mixed infection with Escherichia coli and Mimosella fragilis. In addition, Sulopenem was superior to CZON or cefotiam in a guinea pig model of experimental lung infection (caused by Klebsiella pneumoniae). [2]
Synonyms	CP-70429, CP70429

Chemical Properties

Molecular Weight	349.45
Formula	C₁₂H₁₅NO₅S₃
Cas No.	120788-07-0
Smiles	C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])(SC1S[C@@H]3CS(=O)CC3)[H]
Relative Density.	1.74 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (171.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8616 mL	14.3082 mL	28.6164 mL	143.0820 mL
5 mM	0.5723 mL	2.8616 mL	5.7233 mL	28.6164 mL
10 mM	0.2862 mL	1.4308 mL	2.8616 mL	14.3082 mL
20 mM	0.1431 mL	0.7154 mL	1.4308 mL	7.1541 mL
50 mM	0.0572 mL	0.2862 mL	0.5723 mL	2.8616 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4308 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc