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ABBV-318

Name: ABBV-318
Brand: TargetMol
SKU: T62000
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62000Cas No. 1802848-94-7

ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.

ABBV-318

🥰Excellent

Purity: 99.61%

Catalog No. T62000Cas No. 1802848-94-7

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$74	In Stock
25 mg	$148	In Stock
50 mg	$225	In Stock
100 mg	$338	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Batch Information

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Purity:99.61%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
Targets&IC50	Nav1.7 (human):2.8 μM, Nav1.8 (human):3.3 μM

Chemical Properties

Molecular Weight	405.35
Formula	C₂₀H₁₅F₄N₃O₂
Cas No.	1802848-94-7
Smiles	F[C@@H]1CCN(C1)C(=O)c1ccc2cc(Oc3ccc(cn3)C(F)(F)F)ccc2n1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150.0 mg/mL (370.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4670 mL	12.3350 mL	24.6700 mL	123.3502 mL
5 mM	0.4934 mL	2.4670 mL	4.9340 mL	24.6700 mL
10 mM	0.2467 mL	1.2335 mL	2.4670 mL	12.3350 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4670 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc