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ABBV-318

Name: ABBV-318
Brand: TargetMol
SKU: T62000
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62000Cas No. 1802848-94-7

ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.

ABBV-318

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Purity: 99.84%

Catalog No. T62000Cas No. 1802848-94-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$74	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$225	In Stock	In Stock
100 mg	$338	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

ABBV-318 AI Summary

ABBV-318 exhibits bioactivity related to membrane potential through FRET-Based Membrane Potential Assays on several ion channels, including recombinant human Nav1.7 and Nav1.8 with IC50 values of 2980.0 nM and 3850.0 nM, respectively. It also demonstrates inhibitory activity on human Nav1.5 and rat Nav1.7 channels. Additionally, ABBV-318 shows antinociceptive and antiallodynic effects in rat models of osteoarthritis and neuropathic pain, supported by EC50 values. The compound has good oral bioavailability and pharmacokinetic properties, particularly in rats, dogs, and monkeys, with promising clearance rates and volume of distribution. It also has excellent solubility and permeability, as well as a favorable brain-to-plasma free drug concentration ratio in rats. These attributes suggest that ABBV-318 holds potential for the treatment of pain-related conditions and merits further investigation for its therapeutic application..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
Targets&IC50	Nav1.7 (human):2.8 μM, Nav1.8 (human):3.3 μM

Chemical Properties

Molecular Weight	405.35
Formula	C₂₀H₁₅F₄N₃O₂
Cas No.	1802848-94-7
Smiles	F[C@@H]1CCN(C1)C(=O)c1ccc2cc(Oc3ccc(cn3)C(F)(F)F)ccc2n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (370.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4670 mL	12.3350 mL	24.6700 mL	123.3502 mL
5 mM	0.4934 mL	2.4670 mL	4.9340 mL	24.6700 mL
10 mM	0.2467 mL	1.2335 mL	2.4670 mL	12.3350 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4670 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc