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AT-533

Catalog No. T67836 CAS 908112-37-8

AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K,. AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs).

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AT-533, CAS 908112-37-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
5 mg	In stock	$ 228.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 629.00
50 mg	In stock	$ 896.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 253.00

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Purity: 99.54%

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Description	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K,. AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs).
In vitro	AT-533 (0-1350 nM; 24h or 48h) inhibits 20ng/mL VEGF induced tube formation, cell migration and HUVEC invasion. AT-533 (2 μ M or 75 μ M; 24 h) inhibits HIF-1 α/ VEGF in hypoxia induced breast cancer cells signaling pathway and inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK phosphorylation. AT-533 (10 nM, 50 nM; 48 h) exhibits anti angiogenic ability on the chorionic villus (CAM) model [1]. AT-533 (0.5 μ M; 2 hours, 4 hours) reduces TNF induced by HSV-1 in RAW264.7 and BV2 cells- α、 IL-1 β and the production of IL-6 [2].
In vivo	AT-533 (10 mg/kg; intraperitoneal injection; once a day for 21 days) inhibited the expression of HIF-1 α/ VEGF signaling pathway related proteins in mouse MDA-MB-231 xenograft model of breast cancer [1]. AT-533 (1, 2, 4 mg/kg; intraperitoneal injection; once a day for 30 days) did not cause death, appetite loss, weight loss, or adverse reactions in subacute toxicity tests of Sprague Dawley rats [3].

Molecular Weight	410.51
Formula	C23H30N4O3
CAS No.	908112-37-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.0 mg/mL (73.1 mM)

References and Literature

1. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Viral Compound Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library Exosome Compound Library Bioactive Compounds Library Max

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Keywords

AT-533 908112-37-8 Cytoskeletal Signaling Metabolism Microbiology/Virology HSV HSP AT 533 AT533 Benzamide,2[(trans4hydroxycyclohexyl)amino]4(4,5,6,7tetrahydro3,6,6trimethyl4oxo1Hindazol1yl) inhibitor inhibit

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