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MB-07344

Name: MB-07344
Brand: TargetMol
SKU: T11954
Price: 589 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11954Cas No. 852947-39-8

Alias MB07344, MB 07344

MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.

MB-07344

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Purity: 99.32%

Catalog No. T11954Alias MB07344, MB 07344Cas No. 852947-39-8

MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mL x 10 mM (in DMSO)	$589	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.32%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.
Targets&IC50	Thyroid hormone receptor-β:2.17 nM (Ki)
In vivo	In normal rabbits, MB-07344 (0.05 mg/kg; intravenous injection; 3 times per week for 3 weeks) showed synergistic and additive effects when used in combination with atorvastatin [1].
Synonyms	MB07344, MB 07344

Chemical Properties

Molecular Weight	364.37
Formula	C₁₉H₂₅O₅P
Cas No.	852947-39-8
Smiles	O=P(O)(O)COC=1C=C(C(=C(C1)C)CC2=CC=C(O)C(=C2)C(C)C)C
Relative Density.	1.243 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (548.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (13.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7445 mL	13.7223 mL	27.4446 mL	137.2232 mL
5 mM	0.5489 mL	2.7445 mL	5.4889 mL	27.4446 mL
10 mM	0.2744 mL	1.3722 mL	2.7445 mL	13.7223 mL
20 mM	0.1372 mL	0.6861 mL	1.3722 mL	6.8612 mL
50 mM	0.0549 mL	0.2744 mL	0.5489 mL	2.7445 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc