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MB-07344

Name: MB-07344
Brand: TargetMol
SKU: T11954
Price: 589 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11954Cas No. 852947-39-8

Alias MB07344, MB 07344

MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.

MB-07344

🥰Excellent

Purity: 99.32%

Catalog No. T11954Alias MB07344, MB 07344Cas No. 852947-39-8

MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mL x 10 mM (in DMSO)	$589	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.32%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC) in both combination and monotherapy settings.
Targets&IC50	Thyroid hormone receptor-β:2.17 nM (Ki)
In vivo	In normal rabbits, MB-07344 (0.05 mg/kg; intravenous injection; 3 times per week for 3 weeks) showed synergistic and additive effects when used in combination with atorvastatin [1].
Synonyms	MB07344, MB 07344

Chemical Properties

Molecular Weight	364.37
Formula	C₁₉H₂₅O₅P
Cas No.	852947-39-8
Smiles	O=P(O)(O)COC=1C=C(C(=C(C1)C)CC2=CC=C(O)C(=C2)C(C)C)C
Relative Density.	1.243 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (548.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (13.72 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7445 mL	13.7223 mL	27.4446 mL	137.2232 mL
5 mM	0.5489 mL	2.7445 mL	5.4889 mL	27.4446 mL
10 mM	0.2744 mL	1.3722 mL	2.7445 mL	13.7223 mL
20 mM	0.1372 mL	0.6861 mL	1.3722 mL	6.8612 mL
50 mM	0.0549 mL	0.2744 mL	0.5489 mL	2.7445 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc