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Melanotan (MT)-II

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Catalog No. TP1324Cas No. 121062-08-6

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).

Melanotan (MT)-II

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Catalog No. TP1324Cas No. 121062-08-6

Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$41	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$95	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$428	In Stock	In Stock
200 mg	$623	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH).
In vitro	Melanotan-II (MT-II) acts as a powerful, non-selective agonist targeting melanocortin receptors (MC1, MC3, MC4, and MC5), which play crucial roles in various physiological systems including pigmentation, energy balance, sexual health, immune response, inflammation, and cardiovascular function[1].
In vivo	Melanotan (MT)-II functions as a potent inducer of penile erection, demonstrating dose-dependent activity. It reduces the time until the first erectile event and enhances erectile responses following cavernous nerve stimulation. Research indicates that at a dosage of 1 mg/kg intravenously, MT-II facilitates erection by increasing the erectile response. Additionally, MT-II has been shown to possess neuroprotective qualities and promote peripheral nerve regeneration, particularly highlighted by its significant enhancement of sensory function recovery in rats after sciatic nerve damage when administered at 20 μg/kg every 48 hours subcutaneously. In cases of erectile dysfunction in men, MT-II has proven to be an effective initiator of penile erection. Beyond its effects on erectile and sensory functions, MT-II also impacts metabolic parameters, notably reducing food intake and body weight, while inducing thermogenic responses in mouse models.

Chemical Properties

Molecular Weight	1024.18
Formula	C₅₀H₆₉N₁₅O₉
Cas No.	121062-08-6
Smiles	C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H](NC([C@H](CCCC)NC(C)=O)=O)CC(=O)NCCCC[C@@H](C(N)=O)NC3=O
Relative Density.	1.43 g/cm3
Sequence	Ac-{Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys-NH2, (2→7)-lactam
Sequence Short	{Nle}-DH-{d-Phe}-RWK, (2→7)-lactam

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

H2O: 250 mg/mL (244.1 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	0.9764 mL	4.8820 mL	9.7639 mL	48.8195 mL
5 mM	0.1953 mL	0.9764 mL	1.9528 mL	9.7639 mL
10 mM	0.0976 mL	0.4882 mL	0.9764 mL	4.8820 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0488 mL	0.2441 mL	0.4882 mL	2.4410 mL
50 mM	0.0195 mL	0.0976 mL	0.1953 mL	0.9764 mL
100 mM	0.0098 mL	0.0488 mL	0.0976 mL	0.4882 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc