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Anti-NR0B2 Polyclonal Antibody
(Synonyms: Small heterodimer partner, SHP-1, Shp1, SHP, Orphan nuclear receptor SHP, Nuclear receptor subfamily 0, group B, member 2a, Nuclear receptor subfamily 0 group B member 2, Nr0b2a, NR0B2) Copy Product Info
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Synonyms: Small heterodimer partner, SHP-1, Shp1, SHP, Orphan nuclear receptor SHP, Nuclear receptor subfamily 0, group B, member 2a, Nuclear receptor subfamily 0 group B member 2, Nr0b2a, NR0B2
Catalog No. TMAB-01262 Copy Product Info
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Anti-NR0B2 Polyclonal Antibody is a Rabbit antibody targeting NR0B2. Anti-NR0B2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-NR0B2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Liquid
Color:Transparent
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| Description | Anti-NR0B2 Polyclonal Antibody is a Rabbit antibody targeting NR0B2. Anti-NR0B2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Small heterodimer partner, SHP-1, Shp1, SHP, Orphan nuclear receptor SHP, Nuclear receptor subfamily 0, group B, member 2a, Nuclear receptor subfamily 0 group B member 2, Nr0b2a, NR0B2 |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Dog,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus. |
| Tissue Specificity | Liver. Low levels of expression were detected in heart and pancreas. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions. |
| Immunogen | KLH conjugated synthetic peptide: human NR0B2 |
| Antigen Species | Human |
| Gene Name | NR0B2 |
| Gene ID | |
| Protein Name | Nuclear receptor subfamily 0 group B member 2 |
| Uniprot ID | |
| Biology Area | Retinoic & Retinoid,Lipid metabolism,Retinoic & Retinoid |
| Function | Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. |
| Molecular Weight | Theoretical: 28 kDa. Actual: 28 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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