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Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
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Catalog No. TMAC-02217
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser385). Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody can be used in WB.
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody
😃Good
Catalog No. TMAC-02217
Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser385). Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $217 | 7-10 days | |
| 100 μL | $318 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IRF3 (Ser385). Anti-Phospho-IRF3 (Ser385) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 385 (G-A-S(p)-S-L) derived from Human EGFR |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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