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N6F11
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Catalog No. T77745Cas No. 851398-76-0
N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.
N6F11
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Purity: 99.68%
Catalog No. T77745Cas No. 851398-76-0
N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $692 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
Appearance:Solid
Color:Yellow
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Product Introduction
N6F11 AI Summary
N6F11 exhibits a diverse array of bioactivities. It is a modulator of Lamin A splicing, an inhibitor of Human Jumonji Domain Containing 2E (JMJD2E), and an activator of the Rab9 Promoter. It functions as both an inhibitor and an activator of Leishmania Mexicana Pyruvate Kinase (LmPK) and enhances SMN2 splice variant expression. Additionally, it is utilized as a counterscreen for inhibitors of ROR gamma transcriptional activity and identifies cytotoxic compounds for NIH3T3 cells. It inhibits the replication of Trypanosoma cruzi and serves as an IMPase inhibitor potentiated with lithium. N6F11 shows potential as an inhibitor of the Respiratory Syncytial Virus (RSV) and acts as an inhibitor of BAZ2B, ELG1-dependent DNA repair in HEK293T cells, HP1-beta Chromodomain interactions, TGF-beta, Polymerase Eta, and the malarial parasite plastid. It counteracts TGF-beta binding or entry into cells and inhibits Marburg Virus, Lassa Virus, and Hepatitis C Virus (HCV). The compound also induces DNA re-replication in MCF 10a normal breast cells, serves as an inverse agonist for the GLP-1 Receptor, and shows potential as an agonist for gsp mutation-related Fibrous Dysplasia/McCune-Albright Syndrome. Furthermore, it activates integrin-mediated alleviation for Muscular Dystrophy, induces synthetic lethality in tumor cells producing 2HG, and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT. It is an inhibitor of MBNL1-poly(CUG) RNA binding and TGF-beta in various assays for cytotox counterscreens and confirmation of cherry picks..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer. |
| Molecular Weight | 311.19 |
| Formula | C13H8Cl2N2OS |
| Cas No. | 851398-76-0 |
| Smiles | ClCC1=NC2=C(SC(=C2)C2=CC=C(Cl)C=C2)C(=O)N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.7 mg/mL (72.95 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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