store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 483.00 | |
10 mg | In stock | $ 692.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,490.00 | |
100 mg | In stock | $ 1,970.00 | |
500 mg | In stock | $ 3,930.00 |
Description | JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1. |
In vitro | In HEK293T cells and primary T cells, JI069 (1-10 μM) suppressed STAT3 activation as efficiently as other STATs, including STAT1, STAT5, and STAT6. JI069 effectively suppressed Th1, Th2, and Th17 differentiation while strongly promoting Treg differentiation.[1] |
In vivo | JI069 (25mg/kg weight; i.p.; 6-week-old DBA/1J mice) suppressed symptoms of collagen-induced arthritis (CIA) model in mice and inhibited the cytokine production from T cells as well as the STAT3 phosphorylation of synovial cells.[1] |
Synonyms | WAY-354189 |
Molecular Weight | 387.24 |
Formula | C15H12Cl2N2O4S |
CAS No. | 850019-35-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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JI069 850019-35-1 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT JI 069 WAY-354189 JI-069 WAY 354189 WAY354189 inhibitor inhibit