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MK2-IN-3 hydrate

Name: MK2-IN-3 hydrate
Brand: TargetMol
SKU: T12058
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12058Cas No. 1186648-22-5

Alias MK-2 Inhibitor III

MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)

MK2-IN-3 hydrate

🥰Excellent

Purity: 99.58%

Catalog No. T12058Alias MK-2 Inhibitor IIICas No. 1186648-22-5

MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$58	In Stock
10 mg	$94	In Stock
25 mg	$190	In Stock
50 mg	$277	In Stock
100 mg	$389	In Stock
200 mg	$533	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Batch Information

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Purity:99.58%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
Targets&IC50	MK5:0.081 μM, MK3:0.21 μM, MK2:0.85 nM, MNK1:5.7 μM, ERK2:3.44 μM
In vitro	MK-2 Inhibitor III suppresses TNFα production (IC50 of 4.4 μM, in U397 cells)[1].
Synonyms	MK-2 Inhibitor III

Chemical Properties

Molecular Weight	358.39
Formula	C₂₁H₁₈N₄O₂
Cas No.	1186648-22-5
Smiles	O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.[H]O[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (181.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7903 mL	13.9513 mL	27.9026 mL	139.5128 mL
5 mM	0.5581 mL	2.7903 mL	5.5805 mL	27.9026 mL
10 mM	0.2790 mL	1.3951 mL	2.7903 mL	13.9513 mL
20 mM	0.1395 mL	0.6976 mL	1.3951 mL	6.9756 mL
50 mM	0.0558 mL	0.2790 mL	0.5581 mL	2.7903 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc