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MK2-IN-3 hydrate (Synonyms: MK-2 Inhibitor III)

Name: MK2-IN-3 hydrate
Brand: TargetMol
SKU: T12058
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T12058 Copy Product Info

Purity: 99.58%

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MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)

MK2-IN-3 hydrate

Copy Product Info

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Catalog No. T12058

Synonyms MK-2 Inhibitor III

MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)

Cas No. 1186648-22-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$94	In Stock	In Stock
25 mg	$190	In Stock	In Stock
50 mg	$277	In Stock	In Stock
100 mg	$389	In Stock	In Stock
200 mg	$533	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
Targets&IC50	ERK2:3.44 μM, MK5:0.081 μM, MK2:0.85 nM, MK3:0.21 μM, MNK1:5.7 μM
In vitro	MK-2 Inhibitor III suppresses TNFα production (IC50 of 4.4 μM, in U397 cells)[1].
Synonyms	MK-2 Inhibitor III

Chemical Properties

Molecular Weight	358.39
Formula	C₂₁H₁₈N₄O₂
Cas No.	1186648-22-5
Smiles	O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.[H]O[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (181.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7903 mL	13.9513 mL	27.9026 mL	139.5128 mL
5 mM	0.5581 mL	2.7903 mL	5.5805 mL	27.9026 mL
10 mM	0.2790 mL	1.3951 mL	2.7903 mL	13.9513 mL
20 mM	0.1395 mL	0.6976 mL	1.3951 mL	6.9756 mL
50 mM	0.0558 mL	0.2790 mL	0.5581 mL	2.7903 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc