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UNC2881

Name: UNC2881
Brand: TargetMol
SKU: T2629
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2629Cas No. 1493764-08-1

UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.

UNC2881

🥰Excellent

Purity: 99.85%

Catalog No. T2629Cas No. 1493764-08-1

UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$122	In Stock	In Stock
50 mg	$221	In Stock	In Stock
100 mg	$329	In Stock	In Stock
200 mg	$475	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
Targets&IC50	Mer:4.3 nM
In vitro	In mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%.
In vivo	UNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation.

Chemical Properties

Molecular Weight	463.58
Formula	C₂₅H₃₃N₇O₂
Cas No.	1493764-08-1
Smiles	CCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(NC2CCC(O)CC2)n1
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 85 mg/mL (183.36 mM), Sonication is recommended.

Ethanol: 5 mg/mL (10.78 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1571 mL	10.7856 mL	21.5712 mL	107.8562 mL
5 mM	0.4314 mL	2.1571 mL	4.3142 mL	21.5712 mL
10 mM	0.2157 mL	1.0786 mL	2.1571 mL	10.7856 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1079 mL	0.5393 mL	1.0786 mL	5.3928 mL
50 mM	0.0431 mL	0.2157 mL	0.4314 mL	2.1571 mL
100 mM	0.0216 mL	0.1079 mL	0.2157 mL	1.0786 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc