Shopping Cart

Your shopping cart is currently empty

Candoxatril

Name: Candoxatril
Brand: TargetMol
SKU: T10671
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UK 79300) Copy Product Info

🥰Excellent

Hot

Synonyms: UK 79300

Catalog No. T10671 Copy Product Info

Purity: 99.94%

🥰Excellent

Hot

Candoxatril (UK 79300) is a small-molecule inhibitor and a neutral endopeptidase (NEP) inhibitor with oral activity and cell permeability, used for the treatment of chronic heart failure and capable of improving exercise capacity in patients receiving angiotensin-converting enzyme inhibitor therapy.

Cas No. 123122-55-4

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
1 mg	$293	In Stock	In Stock
5 mg	$719	In Stock	In Stock
10 mg	$987	-	In Stock
25 mg	$1,490	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,750	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.94%

ee:99.84%

Resource Download

COA HNMR LCMS CSFC ORP

Product Introduction

Bioactivity

Description	Candoxatril (UK 79300) is a small-molecule inhibitor and a neutral endopeptidase (NEP) inhibitor with oral activity and cell permeability, used for the treatment of chronic heart failure and capable of improving exercise capacity in patients receiving angiotensin-converting enzyme inhibitor therapy.
In vivo	Methods: A unilateral ureteral obstruction (UUO)-induced renal fibrosis mouse model was used. Candoxatril was administered orally daily at an unspecified dose for 1 consecutive week. Results: Compared with the vehicle control group, Candoxatril significantly increased urinary cGMP levels, reduced renal cortical collagen deposition (from 1.8% to 0.8%) and α-SMA expression (from 8.3% to 4.9%), demonstrating anti-fibrotic effects. [1] Methods: An anesthetized mouse model was used. Candoxatril (5 mg/kg, dissolved in 0.9% NaCl) was administered by intravenous injection, followed by GLP-1(9-36)NH₂ injection 2 minutes later. Results: Compared with the vehicle control group, the Candoxatril pretreatment group showed significantly elevated immunoreactive GLP-1 concentration, indicating effective inhibition of NEP 24.11-mediated degradation of GLP-1 metabolites. [2]
Synonyms	UK 79300

Chemical Properties

Molecular Weight	515.64
Formula	C₂₉H₄₁NO₇
Cas No.	123122-55-4
Smiles	C([C@H](C(OC=1C=C2C(=CC1)CCC2)=O)COCCOC)C3(C(N[C@H]4CC[C@@H](C(O)=O)CC4)=O)CCCC3
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (96.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 5 mg/mL (9.7 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9393 mL	9.6967 mL	19.3934 mL	96.9669 mL
5 mM	0.3879 mL	1.9393 mL	3.8787 mL	19.3934 mL
10 mM	0.1939 mL	0.9697 mL	1.9393 mL	9.6967 mL
20 mM	0.0970 mL	0.4848 mL	0.9697 mL	4.8483 mL
50 mM	0.0388 mL	0.1939 mL	0.3879 mL	1.9393 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc