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Droloxifene

Name: Droloxifene
Brand: TargetMol
SKU: T11098
Price: 592 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11098Cas No. 82413-20-5

Alias 3-Hydroxytamoxifen

Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.

Droloxifene

🥰Excellent

Purity: 99.97%

Catalog No. T11098Alias 3-HydroxytamoxifenCas No. 82413-20-5

Pack Size	Price	Availability
1 mg	$49	In Stock
5 mg	$118	In Stock
10 mg	$178	In Stock
25 mg	$297	In Stock
50 mg	$441	In Stock
100 mg	$592	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.97%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.
In vitro	Droloxifene induces apoptosis in MCF-7 cells(10 nM; 16-18 hours)[1].
In vivo	Droloxifene (5-20 mg/kg,P.o.;Daily for 4 weeks can bring THE BMD of DFM up to 10mg/kg and completely prevent OVX from reducing the BMC and BMD of DFM at 20mg /kg/day[1].
Synonyms	3-Hydroxytamoxifen

Chemical Properties

Molecular Weight	387.51
Formula	C₂₆H₂₉NO₂
Cas No.	82413-20-5
Smiles	CC\C(=C(\c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1
Relative Density.	1.16. Temperature:20 °C.
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (103.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5806 mL	12.9029 mL	25.8058 mL	129.0289 mL
5 mM	0.5161 mL	2.5806 mL	5.1612 mL	25.8058 mL
10 mM	0.2581 mL	1.2903 mL	2.5806 mL	12.9029 mL
20 mM	0.1290 mL	0.6451 mL	1.2903 mL	6.4514 mL
50 mM	0.0516 mL	0.2581 mL	0.5161 mL	2.5806 mL
100 mM	0.0258 mL	0.1290 mL	0.2581 mL	1.2903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc