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Methionine Adenosyltransferase (MAT)

S-Adenosylmethionine synthetase, also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78946 MAT2A-IN-10 2924825-23-8 98%
MAT2A-IN-10
MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].
T79349 MAT2A-IN-11 98%
MAT2A-IN-11
MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an IC...
T79350 MAT2A-IN-12 631897-75-1 98%
MAT2A-IN-12
MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assay...
T10259 AGI-25696 2201066-35-3 98%
AGI-25696
AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies ab...
T5191 PF-9366 72882-78-1 99.74%
PF-9366
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).
T11950 MAT2A inhibitor 2 13299-99-5 99.63%
MAT2A inhibitor 2
MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).
T9262 MAT2A inhibitor 4 1391934-91-0 98.86%
MAT2A inhibitor 4
MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2, which is used in cancer research.
T11284 FIDAS-3 1266684-01-8 98.59%
FIDAS-3
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by...
T73140 MAT2A-IN-9 2439277-80-0 98.53%
MAT2A-IN-9
MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of...
T9050 AG-270 2201056-66-6 98.2%
AG-270
AG-270 is an allosteric and orally active inhibitor of MAT2A.
MAT2A-IN-10
T78946
MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].
MAT2A-IN-11
T79349
MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an IC...
MAT2A-IN-12
T79350
MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assay...
AGI-25696
T10259
AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies ab...
PF-9366
T5191
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).
MAT2A inhibitor 2
T11950
MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).
MAT2A inhibitor 4
T9262
MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2, which is used in cancer research.
FIDAS-3
T11284
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by...
MAT2A-IN-9
T73140
MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of...
AG-270
T9050
AG-270 is an allosteric and orally active inhibitor of MAT2A.
TargetMol