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Chromatin/Epigenetic

DNA Methyltransferase

(45)

Epigenetic Reader Domain

HIF/HIF Prolyl-Hydroxylase

(82)

Histone Acetyltransferase

(50)

Histone Demethylase

(96)

Histone Methyltransferase

Methionine Adenosyltransferase (MAT)

Methionine Adenosyltransferase (MAT)

S-Adenosylmethionine synthetase, also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).

Filter HomeSignaling PathwaysChromatin/EpigeneticMethionine Adenosyltransferase (MAT)

AG-270

T90502201056-66-6In house

AG-270 is an allosteric and orally active inhibitor of MAT2A.

$112

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MAT2A-IN-9

T731402439277-80-0

MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of lymphomas and solid tumors.

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PF-9366

T519172882-78-1In house

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with an IC50 of 420 nM and a Kd of 170 nM.

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FIDAS-3

T112841266684-01-8

FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding.

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MAT2A inhibitor 2

T1195013299-99-5

MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).

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AGI-25696

T102592201066-35-3In house

AGI-25696 is an inhibitor of methionine adenosyltransferase 2A (MATA2). AGI-25696 blocks the growth of MTAP-deleted tumors in vivo and can be used for studies about the treatment of cancer.

$293

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MAT2A inhibitor 4

T92621391934-91-0

MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2, which is used in cancer research.

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MAT2A-IN-17

T2047832447684-81-1

MAT2A-IN-17 is a potent inhibitor of MAT2A, with an IC50 of less than 100 nM. MAT2A-IN-17 is applicable in cancer research.

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10-14 weeks

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MAT2A-IN-19

T2044322850245-72-4

MAT2A-IN-19 (Compound I-3) is an inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 32.93 nM.

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10-14 weeks

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MAT2A-IN-16

T2045063025016-60-5

MAT2A-IN-16 is a MAT2A inhibitor that effectively suppresses the proliferation of MTAP- -HCT-116 cells, with an IC50 value of 20 nM.

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10-14 weeks

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SCR-7952

T2010152798856-04-7

SCR-7952, a MAT2A inhibitor, is utilized in cancer research.

$1,520

4-6 weeks

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MAT2A-IN-21

T2045703062073-94-0

MAT2A-IN-21 (compound 28) is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 49 nM. It selectively inhibits cancer cells with MTAP deficiency.

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10-14 weeks

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MAT2A-IN-10

T789462924825-23-8

MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].

$1,370

8-10 weeks

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MAT2A-IN-12

T79350631897-75-1

MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation assays utilizing the MTAP - - cell line [1].

$1,520

8-10 weeks

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MAT2A-IN-18

T2042092923986-27-8

MAT2A-IN-18 (Compound 15) is an inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC50 of 50 nM or less.

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10-14 weeks

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MAT2A-IN-11

T79349

MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an IC50 value of 6.8 nM [1].

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MAT2A-IN-20

T2042783018834-98-2

MAT2A-IN-20 (Compound A49) is an inhibitor of methionine adenosyltransferase 2A (MAT2A) with an IC50 of ≤50 nM. It also inhibits human UGT1A1 with an IC50 of 28.45 μM. Additionally, MAT2A-IN-20 exhibits antitumor activity in mouse models.

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10-14 weeks

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