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(R)-Simurosertib

Name: (R)-Simurosertib
Brand: TargetMol
SKU: T12642
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12642Cas No. 1330782-69-8

Alias (R)-TAK-931

(R)-Simurosertib ((R)-TAK-931) is an ATP-competitive inhibitor of the cell division cycle 7 (CDC7) kinase.

(R)-Simurosertib

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Purity: 99.89%

Catalog No. T12642Alias (R)-TAK-931Cas No. 1330782-69-8

(R)-Simurosertib ((R)-TAK-931) is an ATP-competitive inhibitor of the cell division cycle 7 (CDC7) kinase.

Pack Size	Price	Availability
2 mg	$29	In Stock
5 mg	$48	In Stock
10 mg	$77	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	(R)-Simurosertib ((R)-TAK-931) is an ATP-competitive inhibitor of the cell division cycle 7 (CDC7) kinase.
Synonyms	(R)-TAK-931

Chemical Properties

Molecular Weight	341.43
Formula	C₁₇H₁₉N₅OS
Cas No.	1330782-69-8
Smiles	Cc1n[nH]cc1-c1cc2nc([nH]c(=O)c2s1)[C@H]1CC2CCN1CC2
Relative Density.	1.67 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 67.5 mg/mL (197.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9289 mL	14.6443 mL	29.2886 mL	146.4429 mL
5 mM	0.5858 mL	2.9289 mL	5.8577 mL	29.2886 mL
10 mM	0.2929 mL	1.4644 mL	2.9289 mL	14.6443 mL
20 mM	0.1464 mL	0.7322 mL	1.4644 mL	7.3221 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	2.9289 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4644 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc