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Brodalumab
🥰Excellent
Catalog No. T76779Cas No. 1174395-19-7
Alias LP 0160, KHK-4827, AMG-827
Brodalumab (AMG 827) is a human monoclonal IgG2 antibody targeting the interleukin 17 receptor (IL-17R), commonly used as an immunosuppressant in treating psoriasis.
Brodalumab
🥰Excellent
Catalog No. T76779Alias LP 0160, KHK-4827, AMG-827Cas No. 1174395-19-7
Brodalumab (AMG 827) is a human monoclonal IgG2 antibody targeting the interleukin 17 receptor (IL-17R), commonly used as an immunosuppressant in treating psoriasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $155 | In Stock | |
| 5 mg | $397 | In Stock | |
| 10 mg | $582 | In Stock | |
| 25 mg | $933 | In Stock | |
| 50 mg | $1,270 | In Stock |
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Concentration:2.48 mg/mL
Purity:> 98.3% (SDS-PAGE); 98.4% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brodalumab (AMG 827) is a human monoclonal IgG2 antibody targeting the interleukin 17 receptor (IL-17R), commonly used as an immunosuppressant in treating psoriasis. |
| In vitro | Brodalumab (AMG 827) blocks the biological activity of the IL-17A, IL-17F, and IL-17A/F heterodimer signaling pathways by binding to the IL-17RA/RC complex. Additionally, it inhibits the biological activity of the IL-25 (IL-17E) signaling pathway by binding to the IL-17RA/RB complex[1]. Brodalumab is capable of suppressing the inflammatory processes associated with psoriasis[1]. |
| Synonyms | LP 0160, KHK-4827, AMG-827 |
| Molecular Weight | 144.06 kDa |
| Cas No. | 1174395-19-7 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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