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Agomelatine (L(+)-Tartaric acid)

🥰Excellent
Catalog No. T10267Cas No. 824393-18-2
Alias S-20098 L(+)-Tartaric acid

Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies.

Agomelatine (L(+)-Tartaric acid)
Other Forms of Agomelatine (L(+)-Tartaric acid):

Agomelatine (L(+)-Tartaric acid)

🥰Excellent
Purity: 99.79%
Catalog No. T10267Alias S-20098 L(+)-Tartaric acidCas No. 824393-18-2
Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$34-In Stock
5 mg$52-In Stock
10 mg$73-In Stock
25 mg$118-In Stock
50 mg$172-In Stock
100 mg$252-In Stock
1 mL x 10 mM (in DMSO)$58-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.79%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies.
Targets&IC50
MT2 (human, CHO cells):0.12 nM (Ki), MT2 (human):0.27 nM (Ki), MT1 (human, CHO cells):0.1 nM (Ki), 5-HT2C receptor (human):6.2 (pKi), MT1 (human):0.06 nM (ki), 5-HT2C receptor (native porcine):6.4 (pKi)
In vitro
In the experimental system where human MT1 receptors (hMT1) and human MT2 receptors (hMT2) are expressed on the cell membranes of CHO cells (or HEK cells), the EC₅₀ values of Agomelatine (L(+)-Tartaric acid) acting on CHO-hMT1 and CHO-hMT2 are 1.6±0.4 nM and 0.10±0.04 nM, respectively[1].
In vivo
Agomelatine (L(+)-Tartaric acid) (25, 50, or 75 mg/kg, intraperitoneal injection) exhibits antioxidant activity in strychnine- or pilocarpine-induced seizure models in mice. However, compared with the control group, Agomelatine (L(+)-Tartaric acid) did not demonstrate any antioxidant effects on oxidative stress-related indicators in pentylenetetrazole (PTZ)- or picrotoxin (PTX)-induced seizure models [3].
SynonymsS-20098 L(+)-Tartaric acid
Chemical Properties
Molecular Weight393.39
FormulaC19H23NO8
Cas No.824393-18-2
Smiles[C@@H]([C@H](C(O)=O)O)(C(O)=O)O.C(CNC(C)=O)C=1C2=C(C=CC(OC)=C2)C=CC1
Relative Density.no data available
ColorWhite
AppearanceViscous
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (203.36 mM), Sonication is recommeded.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5420 mL12.7100 mL25.4201 mL127.1003 mL
5 mM0.5084 mL2.5420 mL5.0840 mL25.4201 mL
10 mM0.2542 mL1.2710 mL2.5420 mL12.7100 mL
20 mM0.1271 mL0.6355 mL1.2710 mL6.3550 mL
50 mM0.0508 mL0.2542 mL0.5084 mL2.5420 mL
100 mM0.0254 mL0.1271 mL0.2542 mL1.2710 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

S-20098 LTartaric acidnative porcine 5-HT2C receptorhuman 5-HT2C receptorHEK-hMT2HEK-hMT1CHO-hMT2CHO-hMT1Agomelatine (LTartaric acid)Agomelatine (L(+)Tartaric acid)Agomelatine (L(+) Tartaric acid)5HTReceptor5HT Receptor
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