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Agomelatine (L(+)-Tartaric acid)
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Catalog No. T10267Cas No. 824393-18-2
Alias S-20098 L(+)-Tartaric acid
Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies.
Agomelatine (L(+)-Tartaric acid)
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Purity: 99.79%
Catalog No. T10267Alias S-20098 L(+)-Tartaric acidCas No. 824393-18-2
Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $34 | - | In Stock | |
| 5 mg | $52 | - | In Stock | |
| 10 mg | $73 | - | In Stock | |
| 25 mg | $118 | - | In Stock | |
| 50 mg | $172 | - | In Stock | |
| 100 mg | $252 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.79%
Appearance:Viscous
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies. |
| Targets&IC50 | MT1 (human, CHO cells):0.1 nM (Ki), MT2 (human, CHO cells):0.12 nM (Ki), 5-HT2C receptor (native porcine):6.4 (pKi), MT2 (human):0.27 nM (Ki), MT1 (human):0.06 nM (ki), 5-HT2C receptor (human):6.2 (pKi) |
| In vitro | In the experimental system where human MT1 receptors (hMT1) and human MT2 receptors (hMT2) are expressed on the cell membranes of CHO cells (or HEK cells), the EC₅₀ values of Agomelatine (L(+)-Tartaric acid) acting on CHO-hMT1 and CHO-hMT2 are 1.6±0.4 nM and 0.10±0.04 nM, respectively[1]. |
| In vivo | Agomelatine (L(+)-Tartaric acid) (25, 50, or 75 mg/kg, intraperitoneal injection) exhibits antioxidant activity in strychnine- or pilocarpine-induced seizure models in mice. However, compared with the control group, Agomelatine (L(+)-Tartaric acid) did not demonstrate any antioxidant effects on oxidative stress-related indicators in pentylenetetrazole (PTZ)- or picrotoxin (PTX)-induced seizure models [3]. |
| Synonyms | S-20098 L(+)-Tartaric acid |
| Molecular Weight | 393.39 |
| Formula | C19H23NO8 |
| Cas No. | 824393-18-2 |
| Smiles | [C@@H]([C@H](C(O)=O)O)(C(O)=O)O.C(CNC(C)=O)C=1C2=C(C=CC(OC)=C2)C=CC1 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (203.36 mM), Sonication is recommeded. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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