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RORγt inverse agonist 13

🥰Excellent
Catalog No. T9623Cas No. 2170477-75-3

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].

RORγt inverse agonist 13

RORγt inverse agonist 13

🥰Excellent
Purity: 99.04%
Catalog No. T9623Cas No. 2170477-75-3
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$118In Stock
10 mg$188In Stock
25 mg$328In Stock
50 mg$467In Stock
100 mg$636In Stock
200 mg$857In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Purity:99.04%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist for RORγt with an IC50 of 63.8 nM, exhibiting improved drug-like properties[1].
Targets&IC50
RORγ:63.8 nM
In vitro
RORγt inverse agonist 13 (Compound 3i) demonstrates 76% inhibition at 0.3 μM in the Th17 cell differentiation assay[1].
In vivo
RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, orally, twice daily) demonstrates an excellent in vivo PK profile and good efficacy in an IMQ-induced psoriasis mouse model[1].
Chemical Properties
Molecular Weight513.29
FormulaC23H17Cl2F3N2O4
Cas No.2170477-75-3
SmilesOC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
Relative Density.1.470 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (19.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9482 mL9.7411 mL19.4822 mL97.4108 mL
5 mM0.3896 mL1.9482 mL3.8964 mL19.4822 mL
10 mM0.1948 mL0.9741 mL1.9482 mL9.7411 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RORγt inverse agonist-13RORγt inverse agonist13RORγt inverse agonist 13RORγtRORrt inverse agonist 13RORgammat inverse agonist 13RORRAR-related orphan receptorInhibitorinhibit
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