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Iptacopan hydrochloride

Name: Iptacopan hydrochloride
Brand: TargetMol
SKU: T9189
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: LNP023 hydrochloride, Iptacopan HCl) Copy Product Info

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Synonyms: LNP023 hydrochloride, Iptacopan HCl

Catalog No. T9189 Copy Product Info

Purity: 99.89%

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Iptacopan hydrochloride (LNP023 hydrochloride) is a small-molecule inhibitor and a complement factor B inhibitor (IC50 = 10 nM, KD = 7.9 nM) with high selectivity, oral activity, and cell permeability, used for the treatment of complement-mediated diseases including paroxysmal nocturnal hemoglobinuria, IgA nephropathy, and C3 glomerulopathy.

Cas No. 1646321-63-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$52	In Stock	In Stock
2 mg	$74	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$206	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$621	In Stock	In Stock
100 mg	$1,030	In Stock	In Stock
200 mg	$1,390	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White to Gray

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Iptacopan hydrochloride (LNP023 hydrochloride) is a small-molecule inhibitor and a complement factor B inhibitor (IC50 = 10 nM, KD = 7.9 nM) with high selectivity, oral activity, and cell permeability, used for the treatment of complement-mediated diseases including paroxysmal nocturnal hemoglobinuria, IgA nephropathy, and C3 glomerulopathy.
Targets & IC50	FB:7.9 nM (KD), FB:10 nM, Membrane aTT cellsack Complex (MAC):130 nM
In vitro	Methods: Different concentrations of Iptacopan hydrochloride were incubated with SPIO NWs, CLIO NWs, Onivyde, PLD, and mRNA LNPs at 37°C for 30 minutes, and C3 deposition and C5a release were detected. Results: Its IC₅₀ was in the low micromolar range, but showed insufficient inhibition against PLD, and the inhibitory effect exhibited donor-dependent variability. [1] Methods: In n144-1.pdf, Iptacopan hydrochloride was used as a complement factor B inhibitor. Different concentrations of the drug were incubated with human serum and various nanoparticles (SPIO NWs, mRNA LNPs, etc.) at 37°C for 30 minutes in vitro, and the inhibitory efficacy was evaluated by detecting C3 deposition and C5a release. Results: IC₅₀ was in the low micromolar range. [2]
In vivo	Methods: Mouse, rat, and Beagle dog models were used to validate the in vivo activity of Iptacopan hydrochloride. The drug premixed with SPIO NWs was administered by intravenous injection (0.63 mg/kg for mice, 0.21–0.99 mg/kg for rats, 0.43 mg/kg for dogs, dissolved in DMSO and mixed with nanoparticles), and detection was performed after single-dose administration. Results:Iptacopan hydrochloride significantly inhibited C3 opsonization, reduced granulocyte uptake, and improved locomotor activity in rats and alleviated blood pressure decline in dogs. [1]
Synonyms	LNP023 hydrochloride, Iptacopan HCl

Chemical Properties

Molecular Weight	458.98
Formula	C₂₅H₃₁ClN₂O₄
Cas No.	1646321-63-2
Smiles	Cl.CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (108.94 mM), Sonication and heating are recommended.

DMSO: 252 mg/mL (549.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1787 mL	10.8937 mL	21.7874 mL	108.9372 mL
5 mM	0.4357 mL	2.1787 mL	4.3575 mL	21.7874 mL
10 mM	0.2179 mL	1.0894 mL	2.1787 mL	10.8937 mL
20 mM	0.1089 mL	0.5447 mL	1.0894 mL	5.4469 mL
50 mM	0.0436 mL	0.2179 mL	0.4357 mL	2.1787 mL
100 mM	0.0218 mL	0.1089 mL	0.2179 mL	1.0894 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Iptacopan hydrochloride chemical structure | Iptacopan hydrochloride in vivo | Iptacopan hydrochloride in vitro | Iptacopan hydrochloride formula | Iptacopan hydrochloride molecular weight