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KP-302

🥰Excellent
Catalog No. T88080Cas No. 2082765-42-0
Alias KP302

KP-302 (compound 23) is a selective protein arginine deaminase 2 (PAD2) inhibitor with a Ki of 60 μM, capable of reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.

KP-302

KP-302

🥰Excellent
Purity: 99.77%
Catalog No. T88080Alias KP302Cas No. 2082765-42-0
KP-302 (compound 23) is a selective protein arginine deaminase 2 (PAD2) inhibitor with a Ki of 60 μM, capable of reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$55In StockIn Stock
5 mg$129In StockIn Stock
10 mg$213In StockIn Stock
25 mg$438In StockIn Stock
50 mg$712In StockIn Stock
100 mg$1,130-In Stock
200 mg$1,530-In Stock
1 mL x 10 mM (in DMSO)$143In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.77%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
KP-302 (compound 23) is a selective protein arginine deaminase 2 (PAD2) inhibitor with a Ki of 60 μM, capable of reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.
Targets&IC50
PAD2:60 μM (Ki), PAD4:180 μM (Ki), PAD1:155 μM (Ki)
SynonymsKP302
Chemical Properties
Molecular Weight365.43
FormulaC20H23N5O2
Cas No.2082765-42-0
Smiles[C@H](NC(=O)C=1N(C)C=CC1)(CCN2C=CN=C2)C(NCC3=CC=CC=C3)=O
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (218.92 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 5 mg/mL (13.68 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7365 mL13.6825 mL27.3650 mL136.8251 mL
5 mM0.5473 mL2.7365 mL5.4730 mL27.3650 mL
10 mM0.2737 mL1.3683 mL2.7365 mL13.6825 mL
20 mM0.1368 mL0.6841 mL1.3683 mL6.8413 mL
50 mM0.0547 mL0.2737 mL0.5473 mL2.7365 mL
100 mM0.0274 mL0.1368 mL0.2737 mL1.3683 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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