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Anti-Annexin V/ANXA5 Antibody (1V816)
😃Good
Catalog No. TMAY-00842
Alias RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5
Anti-Annexin V/ANXA5 Antibody (1V816) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (1V816) can be used in WB,ELISA.
Anti-Annexin V/ANXA5 Antibody (1V816)
Anti-Annexin V/ANXA5 Antibody (1V816)
😃Good
Catalog No. TMAY-00842Alias RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5
Anti-Annexin V/ANXA5 Antibody (1V816) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (1V816) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: WB, ELISA Reactivity: Human |
| Alias | RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5 |
| Ig Type | Mouse IgG2a |
| Clone | 1V816 |
| Reactivity | Human |
| Verified Activity | Anti-Annexin V/ANXA5 mouse monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: Hela Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:35 kDa. -Observed band size:35 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Annexin V/ANXA5 (rh Annexin V/ANXA5; TMPY-02540; P08758; Met1-Asp320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Annexin V/ANXA5 Protein (TMPY-02540) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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