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Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody
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Catalog No. TMAC-00274
Alias p-ARRB1 (Ser412), p-ARRB1 (S412), ARRB1 (p-Ser412), ARRB1 (p-S412)
Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ARRB1 (Ser412). Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody
Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody
😃Good
Catalog No. TMAC-00274Alias p-ARRB1 (Ser412), p-ARRB1 (S412), ARRB1 (p-Ser412), ARRB1 (p-S412)
Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ARRB1 (Ser412). Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody can be used in IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $218 | 7-10 days | 7-10 days | |
| 100 μL | $318 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ARRB1 (Ser412). Anti-Phospho-ARRB1 (Ser412) Polyclonal Antibody can be used in IHC,WB. |
| Synonyms | p-ARRB1 (Ser412), p-ARRB1 (S412), ARRB1 (p-Ser412), ARRB1 (p-S412) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from COS7 cells treated with Etoposide using Arrestin 1 (Phospho-Ser412) Antibody TMAC-00274. The lane on the right is treated with the antigen-specific peptide. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody TMAC-00274 (left) or the same antibody preincubated with blocking peptide (right).   |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-100 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 50 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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