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SJF 1521

Name: SJF 1521
Brand: TargetMol
SKU: T36244
Price: 499 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36244Cas No. 2230821-40-4

SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.

SJF 1521

🥰Excellent

Purity: 99.20%

Catalog No. T36244Cas No. 2230821-40-4

SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$499	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.20%

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COA Element Analysis

Product Introduction

Bioactivity

Description

SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.

Chemical Properties

Molecular Weight	1074.65
Formula	C₅₇H₆₁ClFN₇O₉S
Cas No.	2230821-40-4
Smiles	N(C=1C2=C(C=CC(=C2)C3=CC=C(OCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C=C3)N=CN1)C7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (74.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9305 mL	4.6527 mL	9.3054 mL	46.5268 mL
5 mM	0.1861 mL	0.9305 mL	1.8611 mL	9.3054 mL
10 mM	0.0931 mL	0.4653 mL	0.9305 mL	4.6527 mL
20 mM	0.0465 mL	0.2326 mL	0.4653 mL	2.3263 mL
50 mM	0.0186 mL	0.0931 mL	0.1861 mL	0.9305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc