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Ruzasvir

Catalog No. T68015 CAS 1613081-64-3

Synonyms: MK8408, MK-8408, MK 8408

Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ruzasvir, CAS 1613081-64-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 191.00
5 mg	In stock	$ 480.00
10 mg	In stock	$ 687.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,480.00

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Purity: 97.01%

ee: 100%

Purity: 96.46%

ee: 95.38%

Purity: 96.46%

ee: 95.38%

Biological Description

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Storage & Solubility Information

Description

Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.

In vitro

Ruzasvir (MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50% effective concentrations (EC50s) of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7. The antiviral activity was modestly (10-fold) reduced in the presence of 40% normal human serum. The interaction of Ruzasvir with an NS3/4A protease inhibitor (grazoprevir) and an NS5B polymerase prodrug (uprifosbuvir) was additive to synergistic, with no evidence of antagonism or cytotoxicity.[1]

Synonyms	MK8408, MK-8408, MK 8408
Molecular Weight	947.09
Formula	C49H55FN10O7S
CAS No.	1613081-64-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Asante-Appiah E, et al. In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01280-18. 2. Wyles D, et al. C-CREST Part C and C-SURGE Investigators. Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure. Hepatology. 2017 Dec;66(6):1794-1804.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Inhibitor Library

Related Products

Related compounds with same targets

Danoprevir PSI-6206 Boceprevir HCV-IN-29 FGI-106 tetrahydrochloride EIDD-1931 NS5A-IN-3 2′-O-Methylcytidine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ruzasvir 1613081-64-3 Microbiology/Virology Proteases/Proteasome HCV Protease MK8408 MK-8408 MK 8408 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.