Shopping Cart

Remove All
Your shopping cart is currently empty

Ruzasvir

Name: Ruzasvir
Brand: TargetMol
SKU: T68015
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T68015Cas No. 1613081-64-3

Alias MK-8408, MK8408, MK 8408

Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.

Ruzasvir

🥰Excellent

Purity: 96.88%

Catalog No. T68015Alias MK-8408, MK8408, MK 8408Cas No. 1613081-64-3

Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.

Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$423	In Stock
10 mg	$616	In Stock
25 mg	$959	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:96.88%

ee:95.38%

Resource Download

COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
In vitro	Ruzasvir (MK-8408) was developed as a novel NS5A inhibitor to improve upon the potency and barrier to resistance of early compounds. Ruzasvir inhibited HCV RNA replication with 50% effective concentrations (EC50s) of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7. The antiviral activity was modestly (10-fold) reduced in the presence of 40% normal human serum. The interaction of Ruzasvir with an NS3/4A protease inhibitor (grazoprevir) and an NS5B polymerase prodrug (uprifosbuvir) was additive to synergistic, with no evidence of antagonism or cytotoxicity.[1]
Synonyms	MK-8408, MK8408, MK 8408

Chemical Properties

Molecular Weight	947.09
Formula	C₄₉H₅₅FN₁₀O₇S
Cas No.	1613081-64-3
Smiles	FC1=C2C=3N([C@@H](OC2=CC(=C1)C=4NC(=NC4)[C@H]5N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC5)C=6SC(=NC6)C7CC7)C=8C(C3)=CC(=CC8)C=9NC(=NC9)[C@H]%10N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC%10

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (52.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0559 mL	5.2793 mL	10.5587 mL	52.7933 mL
5 mM	0.2112 mL	1.0559 mL	2.1117 mL	10.5587 mL
10 mM	0.1056 mL	0.5279 mL	1.0559 mL	5.2793 mL
20 mM	0.0528 mL	0.2640 mL	0.5279 mL	2.6397 mL
50 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc