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EG1

Name: EG1
Brand: TargetMol
SKU: T27246
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27246Cas No. 693241-54-2

EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.

EG1

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Purity: 97.48%

Catalog No. T27246Cas No. 693241-54-2

EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$207	In Stock	In Stock
100 mg	$289	In Stock	In Stock
200 mg	$412	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.48%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

EG1 AI Summary

EG1 exhibits a diverse and multi-faceted range of bioactivities. It has inhibitory activity in the Nrf2 qHTS screen with a potency of 29092.9 nM, and also inhibits Human Flap endonuclease 1 (FEN1) with a potency of 79432.8 nM. The compound shows inhibitory effects on FLuc activity under different conditions. In a cell-based assay for miR-21 activity, it demonstrates potent inhibitory effects with a potency of 71.1 nM. Additionally, EG1 inhibits tyrosyl-DNA phosphodiesterase 1 and PI5P4K, with potencies ranging from 18356.4 nM to 29092.9 nM. Assays for GLP-1 Receptor inverse agonists and agonists of gsp indicate activity with potencies of 10000.0 nM and 12589.3 nM, respectively. Furthermore, it shows antagonistic activity in an assay for antagonists of gsp with a potency of 35481.3 nM. Overall, EG1 interacts with various enzymes, miR-21, and specific receptors, highlighting its potential for diverse pharmacological applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.

Chemical Properties

Molecular Weight	390.39
Formula	C₂₂H₁₈N₂O₅
Cas No.	693241-54-2
Smiles	COc1ccccc1C(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O
Relative Density.	1.376 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (153.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5615 mL	12.8077 mL	25.6154 mL	128.0771 mL
5 mM	0.5123 mL	2.5615 mL	5.1231 mL	25.6154 mL
10 mM	0.2562 mL	1.2808 mL	2.5615 mL	12.8077 mL
20 mM	0.1281 mL	0.6404 mL	1.2808 mL	6.4039 mL
50 mM	0.0512 mL	0.2562 mL	0.5123 mL	2.5615 mL
100 mM	0.0256 mL	0.1281 mL	0.2562 mL	1.2808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc