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Eugenin

Name: Eugenin
Brand: TargetMol
SKU: TN1626
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1626Cas No. 480-34-2

Eugenin, a chromone isolated from *Peucedanum japonicum*, exhibits potent antiplatelet aggregation activity.

Eugenin

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Purity: 99.79%

Catalog No. TN1626Cas No. 480-34-2

Eugenin, a chromone isolated from *Peucedanum japonicum*, exhibits potent antiplatelet aggregation activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$269	In Stock	In Stock
50 mg	$395	In Stock	-
100 mg	$563	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Eugenin AI Summary

Eugenin shows a multifaceted profile of both cytotoxic and anti-inflammatory activities. It demonstrates toxicity against Artemia salina with an LC50 value of 112.2 µg/mL, as determined by the Spearman-Karber method. The compound exhibits cytotoxicity against human cancer cell lines A549, MCF7, and HT-29, with GI50 values of 14000.0 nM, 10000.0 nM, and 25000.0 nM, respectively, suggesting potential in inhibiting cell viability and proliferation. Additionally, Eugenin shows notable anti-inflammatory properties, significantly inhibiting cyclooxygenase enzymes COX1 (85.59% inhibition at 30 µM, IC50 = 17800.0 nM) and COX2 (78.5% inhibition at 30 µM, IC50 = 20100.0 nM). It also reduces ear edema and thickness in a TPA-induced mouse edema model. Moreover, Eugenin exhibits antitubercular activity against Mycobacterium tuberculosis H37Rv with a minimum inhibitory concentration of 103.0 µg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Eugenin, a chromone isolated from *Peucedanum japonicum*, exhibits potent antiplatelet aggregation activity.

Chemical Properties

Molecular Weight	206.19
Formula	C₁₁H₁₀O₄
Cas No.	480-34-2
Smiles	COc1cc(O)c2c(c1)oc(C)cc2=O
Relative Density.	1.309g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (145.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (9.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8499 mL	24.2495 mL	48.4990 mL	242.4948 mL
5 mM	0.9700 mL	4.8499 mL	9.6998 mL	48.4990 mL
10 mM	0.4850 mL	2.4249 mL	4.8499 mL	24.2495 mL
20 mM	0.2425 mL	1.2125 mL	2.4249 mL	12.1247 mL
50 mM	0.0970 mL	0.4850 mL	0.9700 mL	4.8499 mL
100 mM	0.0485 mL	0.2425 mL	0.4850 mL	2.4249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc