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Nicotelline

Name: Nicotelline
Brand: TargetMol
SKU: T78135
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78135Cas No. 494-04-2

Alias Nicotellin

Nicotelline (Nicotellin) is a biomarker and environmental tracer for tobacco smoke particles, a relatively non-volatile alkaloid found in tobacco smoke, and a weak inhibitor of cytochrome P-450 2A6 (CYP2A6). It is used to distinguish tobacco products.

Nicotelline

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Purity: 99.92%

Catalog No. T78135Alias NicotellinCas No. 494-04-2

Pack Size	Price	Availability	Quantity
2 mg	$29	In Stock
5 mg	Preferential	In Stock

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Purity:99.92%

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COA

Product Introduction

Bioactivity

Description	Nicotelline (Nicotellin) is a biomarker and environmental tracer for tobacco smoke particles, a relatively non-volatile alkaloid found in tobacco smoke, and a weak inhibitor of cytochrome P-450 2A6 (CYP2A6). It is used to distinguish tobacco products.
Targets&IC50	CYP26:≥300 μM (Ki)
In vitro	Nicotelline can be used as a tracer and biomarker for PM. [1]
Synonyms	Nicotellin

Chemical Properties

Molecular Weight	233.27
Formula	C₁₅H₁₁N₃
Cas No.	494-04-2
Smiles	N1=CC=CC(=C1)C=2N=CC=C(C2)C=3C=NC=CC3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (342.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2869 mL	21.4344 mL	42.8688 mL	214.3439 mL
5 mM	0.8574 mL	4.2869 mL	8.5738 mL	42.8688 mL
10 mM	0.4287 mL	2.1434 mL	4.2869 mL	21.4344 mL
20 mM	0.2143 mL	1.0717 mL	2.1434 mL	10.7172 mL
50 mM	0.0857 mL	0.4287 mL	0.8574 mL	4.2869 mL
100 mM	0.0429 mL	0.2143 mL	0.4287 mL	2.1434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc