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Anti-PRMT6 Antibody (3W571)
😃Good
Catalog No. TMAY-01844
Alias protein arginine methyltransferase 6, HRMT1L6
Anti-PRMT6 Antibody (3W571) is a Mouse antibody targeting PRMT6. Anti-PRMT6 Antibody (3W571) can be used in WB,ELISA.
Anti-PRMT6 Antibody (3W571)
Anti-PRMT6 Antibody (3W571)
😃Good
Catalog No. TMAY-01844Alias protein arginine methyltransferase 6, HRMT1L6
Anti-PRMT6 Antibody (3W571) is a Mouse antibody targeting PRMT6. Anti-PRMT6 Antibody (3W571) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: WB, ELISA Reactivity: Human |
| Alias | protein arginine methyltransferase 6, HRMT1L6 |
| Ig Type | Mouse IgG2b |
| Clone | 3W571 |
| Reactivity | Human |
| Verified Activity | Anti-PRMT6 mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: A431 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:42 kDa. -Observed band size:55 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PRMT6 (rh PRMT6; TMPY-01383; NP_060607.2; Met 1-Asp 375). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. PRMT6 coactivates the progesterone, glucocorticoid and oestrogen receptors in luciferase reporter assays in a hormone-dependent manner. Small interfering RNA (siRNA) oligonucleotide duplex knockdown of PRMT6 disrupts oestrogen-stimulated transcription of endogenous GREB1 and progesterone receptor in MCF-7 breast cancer cells. Neutralizing the activity of PRMT6 could inhibit tumor progression and may be of cancer therapeutic significance. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PRMT6 protein (TMPY-01383) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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